[Inflammatory markers and cytokines in cardiovascular disease].
[Inflammatory markers and cytokines in cardiovascular disease].
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发表时间：
2004-08
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通讯作者：
F. Ogiwara;Masafumi Takahashi;Uichi Ikeda
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作者：
F. Ogiwara;Masafumi Takahashi;Uichi Ikeda
炎症过程在动脉粥样硬化的发病机制中起着关键作用，并介导了从最初的白细胞募集到最终不稳定的动脉粥样硬化斑块破裂的动脉粥样硬化发展阶段。最近的研究表明，一些炎症标志物被认为是动脉粥样硬化和心脏事件的新的可预测的危险因素。在这些标志物中，c反应蛋白（CRP）的研究最为广泛。CRP是在肝脏对白细胞介素-6 （IL-6）的反应中产生的，它是一种急性期反应物，被用作一般的炎症标志物。可检测少量CRP的高敏CRP （hs-CRP）是最近发展起来的，许多大规模的前瞻性研究发现，hs-CRP基线水平升高是心血管事件的独立预测因子。炎症因子如IL-6和肿瘤坏死因子- α (tnf - α)也被评估为预测心血管事件的潜在工具。在这篇综述中，我们重点介绍了最近的报道和炎症标志物和细胞因子作为心血管事件预测工具的潜在用途。
Inflammatory processes play a pivotal role in the pathogenesis of atherosclerosis and mediate the stages of atheroma development from initial leukocyte recruitment to eventual rupture of the unstable atherosclerotic plaque. Recent investigations demonstrated that several inflammatory markers are considered as new predictable risk factors for atherosclerosis and cardiac events. Among these markers, C-reactive protein (CRP) has been most widely studied. CRP is produced in the liver in response to interleukin-6 (IL-6), it is an acute phase reactant and used as a general inflammatory marker. High-sensitivity-CRP (hs-CRP) which could detect a small amount of CRP was recently developed, and numerous large-scale, prospective studies have found that elevated baseline levels of hs-CRP are independent predictor of cardiovascular events. Inflammatory cytokines such as IL-6 and tumor necrosis factor-alpha (TNF-alpha) have also been evaluated as potential tools for prediction of the cardiovascular events. In this review, we focused on the recent reports and potential use of the inflammatory markers and cytokines as a predictable tool for the cardiovascular events.