A neural correlate of response bias in monkey caudate nucleus
A neural correlate of response bias in monkey caudate nucleus
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DOI：
10.1038/nature00892
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发表时间：
2002-07-25
期刊：
影响因子：
64.8
通讯作者：
Hikosaka, O
中科院分区：
文献类型：
--
作者：
Lauwereyns, J;Watanabe, K;Hikosaka, O
灵长类动物的前额皮质 (1-6)、顶叶皮质 (7) 和基底神经节 (6,8-11) 配备有神经回路，可预测在执行行为任务期间获得奖励的情况。然而，尚不清楚奖励价值如何纳入行动控制中。在这里，我们识别了猴子尾状核中的神经元，它们根据预期增益产生空间选择性反应偏差。在行为任务中，猴子在每次试验中都必须进行视觉引导的眼球运动，但只有一半的试验因正确反应而获得奖励。根据视觉目标的空间位置可以预测奖励的可用性。我们发现尾状神经元甚至在视觉目标出现之前就系统地改变了它们的放电率，并且当对侧位置与奖励相关时通常会放电更多。具有对侧偏好的神经元的强烈预期活动与对侧方向眼球运动潜伏期的减少有关。我们得出的结论是，这种神经元机制会产生一种提前偏差，当空间反应与高奖励值相关时，这种偏差有利于空间反应。
Primates are equipped with neural circuits in the prefrontal cortex(1-6), the parietal cortex(7) and the basal ganglia(6,8-11) that predict the availability of reward during the performance of behavioural tasks. It is not known, however, how reward value is incorporated in the control of action. Here we identify neurons in the monkey caudate nucleus that create a spatially selective response bias depending on the expected gain. In behavioural tasks, the monkey had to make a visually guided eye movement in every trial, but was rewarded for a correct response in only half of the trials. Reward availability was predictable on the basis of the spatial position of the visual target. We found that caudate neurons change their discharge rate systematically, even before the appearance of the visual target, and usually fire more when the contralateral position is associated with reward. Strong anticipatory activity of neurons with a contralateral preference is associated with decreased latency for eye movements in the contralateral direction. We conclude that this neuronal mechanism creates an advance bias that favours a spatial response when it is associated with a high reward value.