Does pretreatment HPV viral load correlate with prognosis in patients with early stage cervical carcinoma?
Does pretreatment HPV viral load correlate with prognosis in patients with early stage cervical carcinoma?
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DOI：
10.3802/jgo.2008.19.2.113
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Ryu, Hee-Sug
中科院分区：
文献类型：
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作者：
Kim, Yong Mi;Park, Jin Young;Ryu, Hee-Sug
目的：近期资料表明，HPV(人乳头状瘤病毒)病毒载量的检测有助于预测宫颈上皮内病变的严重程度和制定治疗方案。然而，HPV初始病毒载量与宫颈癌患者预后的关系尚未明确。本研究的目的是确定HPV病毒载量对早期宫颈癌患者的预后是否有意义。方法：对2003年8月至2007年12月在我科接受根治性子宫切除和盆腔淋巴清扫术的所有早期宫颈癌患者进行回顾性分析。患者只有在接受HPVDNA检测前的杂交捕获II试验后才被纳入。结果：我们确定了34名符合纳入标准的患者。确定了两组患者：HPV病毒载量低(100RLU)的患者。两组在年龄、FIGO分期、组织学、病理危险因素(肿瘤大小、深层间质侵犯、淋巴管间隙侵犯、宫旁侵犯、阴道缘侵犯和淋巴结转移)以及辅助CCRT方面没有差异。治疗前HPV病毒载量与治疗前比较无显著差异(P=0.7756)。结论：在本研究中，早期宫颈癌患者治疗前HPV病毒载量低或高的患者，其无病生存期无显著差异。提示治疗前HPV病毒载量对预测疾病预后可能没有帮助。
OBJECTIVE: Recent data suggest that pretreatment HPV (Human papillomavirus) viral load is useful to predict the severity of intraepithelial lesions of the uterine cervix and formulate a treatment plan. However, the relationship between initial HPV viral load and prognosis of cervical cancer patients has not yet been clearly defined. The objective of this study was to determine whether HPV viral load has prognostic significance in patients with early stage cervical carcinoma treated by surgery.METHODS: A retrospective review of all patients with early stage cervical carcinoma who underwent radical hysterectomy and pelvic lymphadenectomy at our institution from August 2003 to December 2007 was conducted. Patients were included only if they had pretreatment Hybrid Capture II test for HPV DNA detection.RESULTS: We identified 34 patients who met the inclusion criteria. Two groups were identified: patients who had low HPV viral load (100 RLU). There were no differences in age, FIGO stage, histology, pathologic risk factors - tumor size, deep stromal invasion, lymph-vascular space invasion, parametrial extensions, vaginal margin involvement, and lymph node metastasis - and adjuvant CCRT. There was no significant difference of disease-free survival regard to pretreatment HPV viral load (p=0.7756).CONCLUSION: In our study, survival was not significantly different between early stage cervical cancer patients who had low and high pretreatment HPV viral load. It seems that pretreatment HPV viral load may not be of help to predict disease prognosis.