Suprachiasmatic Nuclear Lesions Eliminate Circadian Rhythms of Drinking and Activity, but Not of Body Temperature, in Male Rats
Suprachiasmatic Nuclear Lesions Eliminate Circadian Rhythms of Drinking and Activity, but Not of Body Temperature, in Male Rats
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雄性大鼠视交叉上核损伤消除了饮酒和活动的昼夜节律，但不能消除体温节律
DOI：
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发表时间：
1988
影响因子：
3.5
通讯作者：
R. Prosser
中科院分区：
文献类型：
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作者：
E. Satinoff;R. Prosser
雄性Long-Evans大鼠在饮酒时被饲养在避光柜中，活动和遥测体温(TB)数据被收集。损毁视交叉上核(SCN)后，大鼠暴露在12：12的明暗周期中，光照周期延迟6小时，并持续黑暗。取消饮酒和活动节律的病变并不能消除结核病节律。然而，TB节律的幅度、相位和自由运行周期发生了改变。仅部分损伤SCN的损伤也有类似的影响，尽管程度较小。在某些情况下，结核病节律保持正常，活动节律只是暂时中断，饮酒节律在相同的动物中被消除。这些结果支持了这样的结论，即在永久或暂时扰乱其他昼夜节律的病变后，结核病可以保持节律。在这三种节律中，饮酒节律似乎最容易被SCN病变破坏，而结核病节律最不容易被破坏。
Male Long-Evans rats were maintained in lightproof cabinets while drinking, ac tivity, and telemetered body temperature (Tb) data were collected. After suprachiasmatic nuclear (SCN) lesions, the rats were exposed to a 12:12 light-dark cycle, a 6-hr delay in the lighting cycle, and constant dark. Lesions that abolished the drinking and activity rhythms did not eliminate the Tb rhythm. However, the amplitude, phase, and free-running period of the Tb rhythm were altered. Lesions that only partially damaged the SCN had similar, though lesser, effects. In some cases, Tb rhythms remained normal, activity rhythms were only temporarily disrupted, and drinking rhythms were eliminated in the same animals. These results support the conclusion that Tb can remain rhythmic after lesions that permanently or temporarily disrupt other circadian rhythms. Of the three rhythms, it appears that drinking rhythms are most easily and Tb rhythms least easily disrupted by SCN lesions.