Chronic psychophysiological insomnia: Hyperarousal and/or inhibition deficits? An ERPs investigation
Chronic psychophysiological insomnia: Hyperarousal and/or inhibition deficits? An ERPs investigation
复制标题
DOI：
10.1093/sleep/31.6.887
复制
发表时间：
2008-06-01
期刊：
影响因子：
5.6
通讯作者：
Carrier, Julie
中科院分区：
文献类型：
--
作者：
Bastien, Celyne H.;St-Jean, Genevieve;Carrier, Julie
研究目的：慢性原发性失眠被认为是由条件性唤醒或无法启动正常睡眠过程引起的。事件相关电位(ERPs)N1、P2和N350是觉醒的有用指标。研究目的是比较这些事件相关电位在慢性心理生理性失眠症(INS)和睡眠良好者(GS)多次记录中的差异。参与者：15名INS(平均年龄46岁，SD 7.5)和16名GS(平均年龄37岁，SID=10.1)。方法和步骤：在多步骤临床评估之后，INS和GS参与者接受了连续4个晚上的PSG记录(N1到N4)。分别于第3、4晚在睡眠实验室(N3、N4)记录事件相关电位。在两个晚上的清醒过程中(晚上和醒来时)都进行了事件相关电位记录，并在N4上进行了睡眠开始记录。统计分析：对于每种类型的刺激，计算每个事件相关电位的重复测量方差。结果：两组的P2和N350的波幅均大于标准刺激的波幅。早晚INS组N1波幅大于GS组。睡眠开始时，NS组N350波幅大于INS组，P2波幅高于GS组。结论：心理生理性失眠症患者存在较强的皮质觉醒征象，尤其是在清晨醒来时。然而，在睡眠开始时，与睡眠良好的人相比，失眠的人似乎也存在脱离觉醒过程的困难和启动正常睡眠过程的一些能力。
Study Objectives: Chronic primary insomnia has been hypothesized to result from conditioned arousal or the inability to initiate normal sleep processes. The event-related potentials (ERPs) N1, P2, and N350 are useful indexes of arousal. The objective is to compare these ERPs in primary chronic psychophysiological insomniacs (INS) and good sleepers (GS) during multiple recordings.Participants: Participants were 15 INS (mean age = 46 years, SD 7.5) and 16 GS (mean age = 37 years, SID = 10.1).Methods and Procedure: Following a multistep clinical evaluation, INS and GS participants underwent 4 consecutive nights of PSG recordings (N1 to N4). ERPs were recorded on the 3(rd) and 4(th) nights in the sleep laboratory (N3 and N4). ERPs recordings were made during wake on both nights (in the evening and upon awakening), with the addition of sleep-onset recordings on N4. Auditory stimuli consisted of "standard" and "deviant" tones.Statistical Analysis: Repeated measures ANOVAs were computed for each ERP for each recording for each type of stimulus.Results: The amplitude of P2 and N350 was greater for the deviant than for the standard stimulus in both groups. The amplitude of N1 was larger in INS than GS in the morning and the evening. While the amplitude of N350 was larger in GS than in INS at sleep onset, the amplitude of P2 was greater in INS than in GS at that time.Conclusion: Signs of greater cortical arousal in psychophysiological insomnia individuals are observed, especially upon awakening in the morning. However, at sleep onset, difficulties from disengaging from wake processes and some inability at initiating normal sleep processes appear also present in individuals with insomnia compared to good sleepers.