Initial versus recent outcomes with a non–risk adapted surveillance policy in stage I non-seminomatous germ cell tumors (NSGCT)
Initial versus recent outcomes with a non–risk adapted surveillance policy in stage I non-seminomatous germ cell tumors (NSGCT)
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I 期非精原细胞肿瘤 (NSGCT) 中非风险适应监测政策的初始结果与近期结果
DOI：
10.1200/jco.2007.25.18_suppl.5021
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发表时间：
2007
影响因子：
45.3
通讯作者：
M. Moore
中科院分区：
文献类型：
--
作者：
I. Durán;J. Sturgeon;M. Jewett;L. Anson;D. Berthold;D. Kakiashvili;P. Warde;R. Alison;G. Pond;M. Moore
背景：自1981年以来，玛嘉烈医院睾丸癌小组一直将监测作为所有临床I期NSGCT患者(PTS)的首选治疗方案。在一份关于前105例病人的报告中[Sturjo等人。复发率为35%，5年生存率为99%。随着时间的推移，成像技术的改进可能会导致分期迁移，并在该患者群体中总体上复发率较低。我们比较了我们在不同时间点的监控经验。方法：1981年至2004年间，305例I期NS-GCT患者接受了主动监测方案。他们没有按风险分层，只在复发时接受治疗。确定复发率、复发时间、预测复发的危险因素、疾病特异性和总存活率。按时间段分析，根据诊断日期将PTS分为两组。(首字母=1981-1992[N=141]，最近=1993-2004[N=...
5021 Background: Since 1981 the Princess Margaret Hospital testicular cancer group has used surveillance as the preferred management option for all patients (pts) with clinical stage I NSGCT. In a report of the first 105 pts [Sturgeon et al. J Clin Oncol, 1992] the relapse rate was 35% and the disease specific 5-year survival 99%. Improvements in imaging technique over time could cause stage migration with an overall lower relapse rate in this patient population. We compare our experience with surveillance over different time points. Methods: Three-hundred and five pts with stage I NS-GCT were placed on an active surveillance protocol between 1981–2004. They were not stratified by risk and only received treatment on the event of a relapse. Recurrence rates, time to relapse, risk factors predictive for recurrence, disease specific and overall survival were determined. For the analysis by time period, pts were divided in two groups based on diagnosis date. (Initial=1981–1992 [N=141] and Recent=1993–2004 [N=...