Receptor tyrosine kinases: mechanisms of activation and signaling
Receptor tyrosine kinases: mechanisms of activation and signaling
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DOI：
10.1016/j.ceb.2007.02.010
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发表时间：
2007-04-01
影响因子：
7.5
通讯作者：
Miller, W. Todd
中科院分区：
文献类型：
--
作者：
Hubbard, Stevan R.;Miller, W. Todd
受体酪氨酸激酶（RTK）是介导细胞间通讯的信号转导途径的重要组成部分。这些结合多肽配体（主要是生长因子）的单程跨膜受体在细胞生长、分化、代谢和运动等过程中发挥关键作用。最近的进展已经实现了对精确的（和不同的）机制的理解，通过该机制，RTK被配体结合激活，并通过该机制，信号从激活的受体传播到细胞中的下游靶点。
Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.