Recovery of rat muscle size but not function more than 1 year after a single botulinum toxin injection.
Recovery of rat muscle size but not function more than 1 year after a single botulinum toxin injection.
复制标题
单次肉毒毒素注射后 1 年以上，大鼠肌肉大小恢复但功能丧失。
DOI：
10.1002/mus.25707
复制
发表时间：
2018
期刊：
影响因子：
3.4
通讯作者：
Lieber,RichardL
中科院分区：
文献类型：
--
作者：
Ward,SamuelR;Minamoto,VivianeB;Suzuki,KentaroP;Hulst,JonahB;Bremner,ShannonN;Lieber,RichardL
前言神经毒素注射用于治疗多种神经肌肉疾病。本研究的目的是测量注射肉毒毒素的成年大鼠骨骼肌在几乎整个生命周期内的功能和结构特性。方法10组动物分别接受神经毒素注射[肉毒杆菌A型(BT-A)；Allergan，Irvine，California]或生理盐水注射。结果尽管肌肉的结构特征如肌肉质量和纤维面积等有所恢复，但背屈扭矩的产生仍然显著下降25%，即使在注射神经毒素12个月后也是如此。讨论表明，一次注射BT-A后，尽管大体肌肉形态在12个月的时间里得到了恢复，但收缩功能的丧失并没有恢复。肌肉神经57：435-441,2018年
IntroductionNeurotoxin injection is used to treat a wide variety of neuromuscular disorders. The purpose of this study was to measure the functional and structural properties of botulinum toxin–injected adult rat skeletal muscle over nearly the entire lifespan.MethodsTen groups of animals were subjected to either neurotoxin injection [Botox, Type A (BT‐A); Allergan, Irvine, California] or saline solution injection. Neurotoxin‐injected animals (n= 90) were analyzed at different time‐points: 1 week; 1 month; 3 months; 6 months; 12 months; or 18 months.ResultsIn spite of the recovery of structural features, such as muscle mass and fiber area, dorsiflexion torque production remained significantly depressed by 25%, even at 12 months after neurotoxin injection.DiscussionThe data demonstrate that, after a single BT‐A injection, although gross muscle morphology recovered over a 12‐month time period, loss of contractile function did not recover.Muscle Nerve57: 435–441, 2018