Controllable Synthesis of a Smart Multifunctional Nanoscale Metal-Organic Framework for Magnetic Resonance/Optical Imaging and Targeted Drug Delivery
Controllable Synthesis of a Smart Multifunctional Nanoscale Metal-Organic Framework for Magnetic Resonance/Optical Imaging and Targeted Drug Delivery
复制标题
用于磁共振/光学成像和靶向药物输送的智能多功能纳米级金属有机框架的可控合成
DOI：
10.1021/acsami.6b14795
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发表时间：
2017-02-01
影响因子：
9.5
通讯作者：
Damirin, Alatangaole
中科院分区：
文献类型：
--
作者：
Gao, Xuechuan;Zhai, Manjue;Damirin, Alatangaole
由于其非常大的表面和轮廓分明的孔隙，多功能金属有机框架（MOF）的设计对于药物递送至关重要，但很少有报道。本论文旨在开发一种新型的基于纳米多功能微球的药物释放系统，用于肿瘤的诊断和治疗。这种基于MOF的肿瘤靶向DDS是通过简单的合成后表面修饰工艺制备的。首先，磁性介孔纳米材料Fe-MIL-53-NH 2用于封装药物并用作磁共振造影剂。此外，Fe-MIL-53-NH 2纳米材料表现出对模型抗癌药物5-氟尿嘧啶（5 -FU）的高负载能力。随后，将荧光成像剂5-羧基荧光素（5-FAM）和靶向试剂叶酸（FA）缀合到负载5 -FU的Fe-MIL-53-NH 2上，得到高级DDS Fe-MIL-53-NH 2-FA-5-FAM/5-FU。由于多功能表面修饰，所获得的DDS Fe-MIL-53-NH 2-FA-5-FAM/5-FU显示出良好的生物相容性、肿瘤增强的细胞摄取、强的癌细胞生长抑制作用、优异的荧光成像和突出的磁共振成像能力。总之，本研究通过简单有效的策略将诊断和治疗方面整合到一个平台中，旨在促进MOF用于多功能药物递送的新可能性。
As a result of their extraordinarily large surfaces and well-defined pores, the design of a multifunctional metal-organic framework (MOF) is crucial for drug delivery but has rarely been reported. In this paper, a novel drug delivery system (DDS) based on nanoscale MOF was developed for use in cancer diagnosis and therapy. This MOF-based tumor targeting DDS was fabricated by a simple postsynthetic surface modification process. First, magnetic mesoporous nanomaterial Fe-MIL-53-NH2 was used for encapsulating the drug and served as a magnetic resonance contrast agent. Moreover, the Fe-MIL-53-NH2 nanomaterial exhibited a high loading capacity for the model anticancer drug 5-fluorouracil (5 -FU). Subsequently, the fluorescence imaging agent 5-carboxyfluorescein (5-FAM) and the targeting reagent folic acid (FA) were conjugated to the 5 -FU -loaded Fe-MIL-53-NH2, resulting in the advanced DDS Fe-MIL-53-NH2-FA-5-FAM/5-FU. Owing to the multifunctional surface modification, the obtained DDS Fe-MIL-53-NH2-FA-5-FAM/5-FU shows good biocompatibility, tumor enhanced cellular uptake, strong cancer cell growth inhibitory effect, excellent fluorescence imaging, and outstanding magnetic resonance imaging capability. Taken together, this study integrates diagnostic and treatment aspects into a single platform by a simple and efficient strategy, aiming for facilitating new possibilities for MOF use for multifunctional drug delivery.