Model complexes of the active site in peptide deformylase:: A new family of mononuclear N2S-M(II) complexes
Model complexes of the active site in peptide deformylase:: A new family of mononuclear N2S-M(II) complexes
复制标题
DOI：
10.1021/ic001079b
复制
发表时间：
2001-01-15
影响因子：
4.6
通讯作者：
Goldberg, DP
中科院分区：
文献类型：
--
作者：
Chang, SC;Karambelkar, VV;Goldberg, DP
一个新的三齿N2硫醇盐配体，PATH，已被制备，并包括空间位阻脂肪族硫醇盐供体作为半胱氨酸模拟物。利用PATH合成了配合物[（PATH）（MBr）-Br-[]]和[（PATH）（MNCS）-N-[]]（M = Zn，Co），并用X-射线衍射对其进行了表征。这些复合物是肽脱甲酰基酶中发现的His（2）Cys位点的密切结构类似物。
A new tridentate N2Sthiolate ligand, PATH, has been prepared and includes a sterically hindered aliphatic thiolate donor as a cysteine mimic. PATH was employed in the synthesis of the monomeric complexes [(PATH)(MBr)-Br-[]] and [(PATH)(MNCS)-N-[]] (M = Zn, Co), which have been characterized by X-ray diffraction. These complexes are close structural analogues of the His(2)Cys site found in peptide deformylase.