Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer
Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer
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DOI：
10.1245/s10434-008-9833-1
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发表时间：
2008-05-01
影响因子：
3.7
通讯作者：
Evans, Douglas B.
中科院分区：
文献类型：
--
作者：
Hwang, Rosa F.;Wang, Huamin;Evans, Douglas B.
背景：生物标本与可靠临床数据的整合对于将分子结果从实验室推进到临床至关重要。我们描述了胰腺癌和其他胰腺疾病患者的综合胰腺组织库（PTB）和临床数据库的发展。1990年和2000年分别建立了临床数据库和PTB，以收集疑似或确诊胰腺癌、其他胰腺疾病以及十二指肠、乏特壶腹、和远端胆管。结果：从2000年到2006年，PTB从620名患者中收集了8,061份胰腺组织标本。胰腺肿瘤最常见的组织学类型为胰腺导管腺癌（55.3%）和神经内分泌癌（16.3%）。生物标本收集还包括431个血浆样本，40个细针穿刺样本，以及包含85个胰腺癌和匹配的正常组织样本的组织微阵列。临床数据库包含7，647例胰腺癌、其他胰腺疾病以及十二指肠、壶腹或胆管肿瘤患者的信息。数据被安排成9个模块：病人，介绍，危险因素，诊断影像，治疗计划，手术，病理，术后并发症，和follow-up.Conclusions：我们已经建立了一个胰腺癌组织库与标准化程序收集生物标本沿着与一个全面的多学科的临床数据库。这里描述的胰腺癌的综合生物标本库和临床数据库可以作为其他小组开发类似系统的模型。
Background: The integration of biospecimens with reliable clinical data is critical to advance molecular findings from the laboratory to the clinic. We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders.Methods: A clinical database and PTB were created in 1990 and 2000, respectively, to collect clinical information and biospecimens from patients with suspected or confirmed pancreatic cancer, other pancreatic diseases, and tumors of the duodenum, ampulla of Vater, and distal bile duct. Standard procedures for biospecimen collection and data entry were developed.Results: From 2000 through 2006, the PTB collected 8,061 pancreatic tissue specimens from 620 patients. The most common histologies of pancreatic tumors were pancreatic ductal adenocarcinoma (55.3%) and neuroendocrine carcinoma (16.3%). The biospecimen collection also includes 431 plasma samples, 40 fine-needle aspiration samples, and a tissue microarray containing 85 pancreatic adenocarcinomas and matched normal tissue specimens. The clinical database contains information for 7,647 patients with pancreatic cancer, other pancreatic disorders, and duodenal, ampullary, or bile duct neoplasms. The data are arranged into nine modules: patient, presentation, risk factors, diagnostic imaging, treatment plan, surgery, pathology, postoperative complications, and follow-up.Conclusions: We have established a pancreatic cancer tissue bank with standardized procedures for collection of biospecimens along with a comprehensive multidisciplinary clinical database. The integrated biospecimen bank and clinical database for pancreatic cancer described here can serve as a model from which other groups may develop similar systems.