Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure
Effects of yoga on inflammation and exercise capacity in patients with chronic heart failure
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DOI：
10.1016/j.cardfail.2007.12.007
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发表时间：
2008-06-01
影响因子：
6
通讯作者：
Khan, Bobby V.
中科院分区：
文献类型：
--
作者：
Pullen, Paula R.;Nagamia, Sameer H.;Khan, Bobby V.
背景：尽管最近在药物和器械治疗方面取得了进展，但心力衰竭（HF）的发病率和死亡率仍然很高。瑜伽结合物理和呼吸练习，可能有利于患者HE我们假设，8周的瑜伽方案，除了标准的药物治疗将提高运动能力，炎症标志物和生活质量（QoL）在HF.Methods和结果：纽约心脏协会I-III级HF患者被随机分配到瑜伽治疗（YT）或标准的药物治疗（MT）。测量包括分级运动试验（GXT）至VO 2峰值和以下血清生物标志物：白细胞介素-6（IL-6）、高敏C反应蛋白（hsCRP）和细胞外超氧化物歧化酶（EC-SOD）。采用明尼苏达心力衰竭生活质量问卷（MLHFQ）评估QoL的变化。初次筛选后共入组19例患者。19例患者中，9例随机分配至YT组，10例随机分配至MT组。患者的平均EF为25%。与MT组相比，YT组的GXT时间和VO 2峰值显著改善（YT组为+18%，MT组为-7.5%，P = .03，与对照组相比，YT组为+17，MT组为-7.1，P = .02）。YT组血清IL-6和hsCRP水平显著降低，EC-SOD水平显著升高（均P <0.005 vs MT）。MLHFQ分数提高了25.7%，在YT组和MT group.Conclusions的2.9%：瑜伽改善运动耐量和积极影响HF患者的炎症标志物水平，也有改善生活质量的趋势。
Background: Despite recent advances in pharmacologic and device therapy, morbidity and mortality from heart failure (HF) remain high. Yoga combines physical and breathing exercises that may benefit patients with HE We hypothesized that an 8-week regimen of yoga in addition to standard medical therapy would improve exercise capacity, inflammatory markers, and quality of life (QoL) in patients with HF.Methods and Results: New York Heart Association Class I-III HF patients were randomized to yoga treatment (YT) or standard medical therapy (MT). Measurements included a graded exercise test (GXT) to VO2Peak and the following serum biomarkers: interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and extracellular superoxide dismutase (EC-SOD). The Minnesota Living with Heart Failure Questionnaire (MLHFQ) was administered to assess changes in QoL. A total of 19 patients were enrolled after the initial screening. Of the 19 patients, 9 were randomized to YT and 10 to MT. Patients had a mean EF of 25%. GXT time and VO2Peak were significantly improved in the YT versus MT groups (+18% in the YT and -7.5% in MT; P = .03 vs. control and +17 in YT and -7.1 in MT; P = .02, respectively). There were statistically significant reductions in serum levels of IL-6 and hsCRP and an increase in EC-SOD in the YT group (all P < .005 vs. MT). MLHFQ scores improved by 25.7% in the YT group and by 2.9% in the MT group.Conclusions: Yoga improved exercise tolerance and positively affected levels of inflammatory markers in patients with HF, and there was also a trend toward improvements in QoL.