Human chorionic gonadotropin--a hormone secreted for many reasons.
Human chorionic gonadotropin--a hormone secreted for many reasons.
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DOI：
10.1056/nejm197908093010609
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发表时间：
1979-08
期刊：
影响因子：
--
通讯作者：
J. Vaitukaitis
中科院分区：
文献类型：
--
作者：
J. Vaitukaitis
人绒毛膜促性腺激素是一种由胎盘大量分泌的糖蛋白激素，通常仅在妊娠期以易于检测的水平在体内循环。它与垂体糖蛋白激素——黄体生成素、卵泡刺激素和促甲状腺激素具有由两个不同亚单位（分别称为α和β）构成的共同四级结构。尽管人糖蛋白激素的α亚单位的氨基酸序列基本相同，但β亚单位的氨基酸序列不同，这决定了每种糖蛋白激素独特的免疫和生物学活性。1尽管黄体生成素和人绒毛膜促性腺激素具有一些共同的生物学活性，反映出80%……
Human chorionic gonadotropin, a glycoprotein hormone secreted in large quantities by the placenta, normally circulates at readily detectable levels only during gestation. It shares a common quaternary structure of two dissimilar subunits (designated alpha and beta) with the pituitary glycoprotein hormones luteinizing hormone, follicle-stimulating hormone and thyroid-stimulating hormone. Although the amino-acid sequences of the alpha subunits of the human glycoprotein hormones are essentially identical, those of the beta subunits differ and account for the unique immunologic and biologic activities of each glycoprotein hormone.1 Although luteinizing hormone and human chorionic gonadotropin have biologic activities in common, reflecting the 80 per cent . . .