Is replacement of albumin in major abdominal surgery useful?
Is replacement of albumin in major abdominal surgery useful?
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DOI：
10.1016/j.jclinane.2010.06.007
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发表时间：
2011-02-01
影响因子：
6.7
通讯作者：
Kompan, Lidija
中科院分区：
文献类型：
--
作者：
Mahkovic-Hergouth, Ksenija;Kompan, Lidija
研究目的：回顾性评价腹部手术患者（低白蛋白血症）未接受人白蛋白溶液与接受人白蛋白溶液的患者的血清白蛋白浓度、发病率和死亡率。设计：回顾性观察性研究。单位：学术社区医院。测量：回顾了76例连续接受选择性腹部手术的患者的记录。记录术前和术后至术后第7天的血清白蛋白浓度。随访患者的发病率和死亡率，直至出院。结果：38例低白蛋白血症患者接受白蛋白替代与38例未接受白蛋白替代的患者在累积（P < 0.52）或单个术后并发症（感染P < 0.35，心血管并发症P < 1.0，器官衰竭P < 0.67，血栓栓塞事件P < 0.26）和死亡率（P < 0.47）方面无显著差异。结论：术后血清白蛋白浓度与术后发病率无相关性。腹腔肿瘤手术患者围手术期白蛋白替代治疗没有正当理由。(C) 2011爱思唯尔公司版权所有。
Study Objective: To evaluate retrospectively serum albumin concentrations as well as morbidity and mortalitiy of abdominal surgical patients who -if hypoalbuminemic- did not receive human albumin solutions versus those who did receive such solutions.Design: Retrospective observational study.Setting: Academic community hospital.Measurements: The records of 76 consecutive patients who had undergone elective abdominal surgery were reviewed. Preoperative and postoperative serum albumin concentrations up to the seventh day after surgery were recorded. Morbidity and mortality were followed until the time of discharge from the hospital.Results: 38 patients who received albumin replacement if they were hypoalbuminemic versus 38 patients who did not receive albumin replacement showed no significant difference in cumulative (P < 0.52) or individual postoperative complications (infections P < 0.35, cardiovascular complications P < 1.0, organ failure P < 0.67, thromboembolic incidents P < 0.26), and mortality (P < 0.47).Conclusions: Postoperative serum albumin concentration had no correlation with postoperative morbidity. There is no justification for perioperative albumin replacement in abdominal cancer surgical patients. (C) 2011 Elsevier Inc. All rights reserved.