Improving quick and accurate diagnosis of childhood JIA-uveitis from a pediatric rheumatology perspective.
Improving quick and accurate diagnosis of childhood JIA-uveitis from a pediatric rheumatology perspective.
复制标题
从儿科风湿病学角度提高儿童幼年特发性葡萄膜炎的快速准确诊断。
DOI：
10.1080/17469899.2020.1739521
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发表时间：
2020
影响因子：
0.7
通讯作者：
Angeles-Han,Sheila
中科院分区：
文献类型：
--
作者：
Rodriguez-Smith,Jackeline;Yeh,Steven;Angeles-Han,Sheila
幼年特发性关节炎（JIA）是最常见的儿童风湿性疾病与葡萄膜炎。JIA相关性葡萄膜炎（JIA-U）通常无症状，慢性，可导致危及视力的并发症。本综述将提供改善JIA-U患儿诊断和预后的方法。涉及的领域：我们将提供葡萄膜炎发病和眼部并发症的危险因素的更新，葡萄膜炎检测的眼科筛查时间表的改进，以及使用先进的眼科成像和诊断设备和实验室生物标志物推进JIA-U诊断和监测的潜在策略。专家意见：在JIA-U缺乏高质量的研究，随机对照试验很少，强调了在这一人群中进行进一步研究的迫切需要。早期葡萄膜炎诊断结合及时和适当的治疗可以改善视力结果。加深对葡萄膜炎发病机制、葡萄膜炎发病的危险因素、葡萄膜炎结局的测量和最佳治疗的了解至关重要。
Introduction: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease associated with uveitis. JIA-associated uveitis (JIA-U) is typically asymptomatic, chronic, and can lead to sight-threatening complications. This review will provide approaches to improve the diagnosis and outcomes of children with JIA-U.Areas covered: We will provide updates on risk factors for uveitis onset and ocular complications, improvements in the ophthalmic screening schedule for uveitis detection, and potential strategies to advance the diagnosis and monitoring of JIA-U using advanced ophthalmic imaging and diagnostic equipment and laboratory biomarkers.Expert opinion: There is a lack of high-quality research in JIA-U and few randomized controlled trials, underscoring the urgent need for further studies in this population. Early uveitis diagnosis combined with timely and appropriate treatment can improve visual outcomes. Improved knowledge of uveitis pathogenesis, risk factors for uveitis onset, measurement of uveitis outcomes, and optimal treatment are crucial.