Age of the last common ancestor of extant Plasmodium parasite lineages
Age of the last common ancestor of extant Plasmodium parasite lineages
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现存疟原虫寄生虫谱系最后共同祖先的年龄
DOI：
10.1016/j.gene.2012.04.037
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发表时间：
2012
期刊：
影响因子：
3.5
通讯作者：
Kazuyuki Tanabe.(7人中7番目)
中科院分区：
文献类型：
--
作者：
Toshiyuki Hayakawa;Shin-Ichiro Tachibana;Kenji Hikosaka;Nobuko Arisue;Atsushi Matsui;Toshihiro Horii;Kazuyuki Tanabe.(7人中7番目)
疟原虫属寄生虫感染所有类别的羊膜动物（哺乳动物、鸟类和爬行动物），并在其感染中显示宿主特异性。因此，人们普遍认为疟原虫与它们的宿主密切地共同进化。在这里，我们报告了基于对核基因组中22个基因的进化分析，现存的疟原虫谱系大约起源于其宿主出现后的渐新世。现存疟原虫共同祖先的这个时间点表明了宿主转换的重要性，并支持了基于线粒体基因组进化分析提出的“疟疾大爆炸”的进化设想。
Parasites of the genus Plasmodium infect all classes of amniotes (mammals, birds and reptiles) and display host specificity in their infections. It is therefore generally believed that Plasmodium parasites co-evolved intimately with their hosts. Here, we report that based on an evolutionary analysis using 22 genes in the nuclear genome, extant lineages of Plasmodium parasites originated roughly in the Oligocene epoch after the emergence of their hosts. This timing on the age of the common ancestor of extant Plasmodium parasites suggest the importance of host switches and lends support to the evolutionary scenario of a “malaria big bang” that was proposed based on the evolutionary analysis using the mitochondrial genome.