Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain
Age effects on pain thresholds, temporal summation and spatial summation of heat and pressure pain
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DOI：
10.1016/j.pain.2005.03.025
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发表时间：
2005-06-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, L
中科院分区：
文献类型：
--
作者：
Lautenbacher, S;Kunz, M;Arendt-Nielsen, L
到目前为止，与年龄相关的痛觉变化的实验数据一直是相互矛盾的，在这方面，似乎疼痛诱导方法的类型是关键，老年人对热痛的敏感度降低，而对压痛的敏感度甚至可能增强。此外，已有研究表明，热痛的时间总和在老年人中更加明显，但尚不清楚在使用其他疼痛诱导方法时，时间总和的年龄差异是否也明显。到目前为止，还没有关于疼痛空间总和与年龄相关的变化的研究，本研究的目的是提供与年龄相关的疼痛知觉变化的综合调查，即躯体感觉阈值(温暖)。冷、震动)、痛阈值(热。压力)和热痛和压痛的时空总和。我们调查了20名年轻人(平均年龄27.1岁)和20名老年人(平均年龄71.6岁)。我们的结果证实并扩展了先前的发现，表明非伤害性刺激的声感觉阈值随着年龄的增加而增加，而压力痛阈值降低，热痛阈值没有显示出与年龄相关的变化，除了热痛的时间总和增强外，疼痛总和没有被发现受到年龄的严重影响。本研究的结果为老年人痛觉的刺激特异性变化提供了证据，深层组织(肌肉)伤害感(受年龄的影响不同于浅表组织(皮肤)伤害感)。总和机制对疼痛知觉的年龄变化只有适度的贡献。(C)2005年国际疼痛研究协会。爱思唯尔出版，版权所有。
Experimental data on age-related changes in pain perception have so far been contradictory, It has appeared that the type of pain induction method is critical in this context, with sensitivity to heat pain being decreased whereas sensitivity to pressure pain may lie even enhanced in the elderly. Furthermore, it has been shown that temporal summation of heat pain is more pronounced in the elderly but it has remained unclear whether age differences in temporal summation are also evident when using other pain induction methods. No Studies on age-related changes in spatial summation of pain have so far been conducted, The aim of the present Study was to provide a comprehensive survey on age-related changes in pain perception, i,e, in somatosensory thresholds (warmth. cold, vibration), pain thresholds (heat. pressure) and spatial and temporal summation of heat and pressure pain. We investigated 20 Young (mean age 27.1 years) and 20 elderly (mean age 71,6 years) subjects. Our results confirmed and extended previous findings by showing that soniatosensory thresholds for non-noxious, stimuli increase with age whereas pressure pain thresholds decrease and heat pain thresholds show no age-related changes, Apart from an enhanced temporal summation of heat pain, pain summation was not found to be critically affected by age. The result,, of the present study provide evidence for stimulus-specific changes in pain perception in the elderly, with deep tissue (muscle) nociception being affec(ed differently by age than superficial tissue (skin) nociception. Summation mechanisms contribute only moderately to age changes in pain perception. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V, All rights reserved.