Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes
Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes
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DOI：
10.1016/j.placenta.2017.10.006
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发表时间：
2017-12-01
期刊：
影响因子：
3.8
通讯作者：
Welch, Martha G.
中科院分区：
文献类型：
--
作者：
Firestein, Morgan R.;Abellar, Rosanna;Welch, Martha G.
滋养细胞包涵体（TIs）是滋养细胞双分子层的胎盘异常。存在于2-8%的足月胎盘中，它们与神经发育不良有关，包括自闭症。虽然以前没有研究过，但对108个早产儿的绒毛膜绒毛的检查显示，ti的频率增加了4倍（30.5%）。ti的发生频率与胎龄（GA）呈负相关；32周的胎盘中有43%出现TIs （chi 2 - 4.41, p = 0.036）。早产儿患病率的增加表明，TIs可能表明不良的宫内过程或未被发现的遗传异常，并可能识别出有神经发育不良风险的婴儿。(c) 2017 Elsevier Ltd.版权所有。
Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2-8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a similar to 4 fold increase in the frequency of TIs (30.5%). Frequency of TIs was inversely related to gestational age (GA); 43% of placentas = 32 weeks had TIs (chi 2 - 4.41, p = 0.036). This increased prevalence in preterm infants suggests that TIs may indicate adverse intrauterine processes or undetected genetic abnormalities and could identify infants at risk for poor neurodevelopment. (c) 2017 Elsevier Ltd. All rights reserved.