Old Key Opens the Lock in Carborane: The in Situ NHC-Palladium Catalytic System for Selective Arylation of B(3,6)-H Bonds of o-Carboranes via B-H Activation
Old Key Opens the Lock in Carborane: The in Situ NHC-Palladium Catalytic System for Selective Arylation of B(3,6)-H Bonds of o-Carboranes via B-H Activation
复制标题
旧钥匙打开碳硼烷之锁：原位 NHC-钯催化系统通过 B-H 活化选择性芳基化邻碳硼烷的 B(3,6)-H 键
DOI：
10.1021/acs.orglett.9b03790
复制
发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Yang Junxiao
中科院分区：
文献类型：
--
作者：
Xu Tao-Tao;Cao Ke;Zhang Cai-Yan;Wu Ji;Ding Li-Fang;Yang Junxiao
首次建立了一种用于邻碳硼烷B(3，6)-H键区域选择性芳基化反应的Pd-NHC原位催化体系。在温和的反应条件下，合成了一系列带有活性基团的对称和不对称3，6-二芳基-o-碳硼烷，产率中等到很高。这项工作为B(3，6)-H键的选择性活化提供了一种有效的方案，对设计邻碳硼烷选择性官能化的偶联反应具有重要的价值。
An efficient in situ Pd-NHC catalytic system for regioselective arylation of B(3,6)–H bonds ofo-carborane has been developed for the first time. A series of symmetric and unsymmetric 3,6-diaryl-o-carboranes anchored with active groups have been synthesized with moderate to good yields under mild conditions. This work offers an efficient protocol for selective activation of B(3,6)–H bonds and has important value in design coupling reactions for selective functionalization ofo-carboranes.