Phonation threshold flow measurements in normal and pathological phonation.
Phonation threshold flow measurements in normal and pathological phonation.
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DOI：
10.1002/lary.20165
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发表时间：
2009-04
期刊：
影响因子：
2.6
通讯作者：
Wei, Chun Sheng
中科院分区：
文献类型：
--
作者：
Zhuang, Peiyun;Sprecher, Alicia J.;Hoffman, Matthew R.;Zhang, Yi;Fourakis, Marios;Jiang, Jack J.;Wei, Chun Sheng
发声阈值流量(PTF)可作为评估喉功能的一种工具，并可区分正常嗓音和病态嗓音。息肉和小结都通过造成声门不完全闭合和声带质量和厚度增加而导致PTF增加。前瞻性研究。用Kay Elemetrics语音空气动力学系统(PAS)测量了40例正常人、21例声带小结和23例声带息肉患者的平均血流速度(MFR)和平均血流速度(PTF)。基于性别的差异使用t检验进行评估。用单因素方差分析判断声带病理对PTF和MFR的影响。使用接收器操作特征(ROC)分析评估诊断潜力。Ptf(p=0.047)和MFR(p=0.008)均受性别的显著影响。使用双因素方差分析并校正性别差异后，病理对PTF的影响被确定为显著(p<；0.001)。事后测试发现，正常受试者和息肉受试者之间有显著差异(p<；0.001)，但正常受试者和结节受试者(p=0.177)或结节和息肉受试者(p=0.246)之间没有显著差异。ROC分析发现，PTF(AUC=0.691)和MFR(AUC=0.684)具有相似的诊断价值。PTF可用于区分正常嗓音和病理嗓音。作为一个实验上对生物力学参数敏感的参数，为其提供了理论依据，可用于临床分析喉功能。未来的研究可能集中在测量其他病理情况下的PTF，如瘫痪或疤痕形成，这也将影响发声所需的努力。
Phonation threshold flow (PTF) may provide a tool to assess laryngeal function and could differentiate between normal and pathological voices. Both polyps and nodules contribute to an increased PTF by creating an incomplete glottal closure and increased vocal fold mass and thickness. Prospective study. The Kay Elemetrics Phonatory Aerodynamic System (PAS) was used to collect mean flow rate (MFR) and PTF measurements from 40 normal subjects, 21 patients with vocal fold nodules, and 23 patients with vocal fold polyps. Gender based differences were assessed using a t-test. The effect of vocal pathology on PTF and MFR was determined with an ANOVA. Diagnostic potential was evaluated using a receiver operation characteristics (ROC) analysis. Both PTF (p=0.047) and MFR (p=0.008) were significantly affected by gender. Using a two-way ANOVA and correcting for gender differences, the influence of pathology on PTF was determined to be significant (p<0.001). Post-hoc tests found a significant difference between normal and polyp subjects (p<0.001), but not normal and nodule subjects (p=0.177) or nodule and polyp subjects (p=0.246). ROC analysis found that PTF (AUC=0.691) and MFR (AUC=0.684) had a similar diagnostic utility. PTF can be used to differentiate between normal and pathological voices. As a parameter which is experimentally sensitive to the biomechanical parameters providing its theoretical basis, it could be used clinically to analyze laryngeal functionality. Future research could focus on measuring PTF in other pathologies, such as paralysis or scarring, which would also affect the effort required to produce voice.
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影响因子：
2.2
作者：
HERTEGARD, S;GAUFFIN, J;LINDESTAD, PA
通讯作者：
LINDESTAD, PA
影响因子：
2.2
作者：
TITZE, IR
通讯作者：
TITZE, IR
影响因子：
3.4
作者：
Cohen, Seth M.;Garrett, C. Gaelyn
通讯作者：
Garrett, C. Gaelyn
DOI：
10.1097/00020840-200312000-00009
发表时间：
2003-12-01
影响因子：
1.6
作者：
Johns, Michael M
通讯作者：
Johns, Michael M
影响因子：
1.4
作者：
Jiang, J;Stern, J;Solomon, NP
通讯作者：
Solomon, NP