Subtypes of purinoceptors in rat and dog urinary bladder smooth muscles
Subtypes of purinoceptors in rat and dog urinary bladder smooth muscles
复制标题
大鼠和狗膀胱平滑肌嘌呤受体的亚型
DOI：
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发表时间：
1994
影响因子：
7.3
通讯作者：
S. Kokubun
中科院分区：
文献类型：
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作者：
Hideka Suzuki;S. Kokubun
1 Both adenosine and adenosine 5′‐triphosphate (ATP) (10 μm and 100 μm) relaxed 10 μm acetylcholine (ACh)‐induced contraction of rat bladder strips, which was completely antagonized by 100 μm 8‐(p‐sulphophenyl) theophylline. In dog bladder neither adenosine nor ATP inhibited ACh‐induced contraction. 2 P2x‐purinoceptor agonists contracted both rat and dog bladder strips with the potency order of α,β‐MeATP > ATP > ADP. 3 α,β‐MeADP (100 μm) induced a contraction of the rat bladder strip even after desensitization of P2x‐purinoceptors but failed to contract the dog bladder strip. 4 2‐MeSATP (1 μm to 300 μm) concentration‐dependently induced contraction of rat bladder strips; this contraction was significantly inhibited after desensitization of P2x‐purinoceptors. Cibacron blue 3GA (100 μm) antagonized the drug at concentrations lower than 30 μm, whereas it augmented the response to the drug at concentrations above 30 μm. 5 ADPβS (1 μm to 1 mm) concentration‐dependently induced contraction of rat bladder strips after desensitization of P2x‐purinoceptors; a contraction which was significantly antagonized by cibacron blue 3GA (100 μm). 6 It is concluded that three subtypes of purinoceptors, P1 (mediating relaxation), and P2x and another type of P2 (mediating contraction), exist in rat urinary bladder smooth muscle, whereas a single subtype of the receptor, P2x‐purinoceptor (mediating contraction) occurs in dog urinary bladder smooth muscle.
P2Y 嘌呤能受体激动剂和鸟嘌呤核苷酸激活磷脂酶 C 的动力学。
DOI：
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发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Boyer,JL;Downes,CP;Harden,TK
通讯作者：
Harden,TK
比较 ATP 拮抗剂芳基叠氮氨基丙酰 ATP (ANAPP3) 对豚鼠输精管平滑肌对 ATP 和相关核苷酸反应的影响。
影响因子：
5
作者：
Fedan,JS;Hogaboom,GK;Westfall,DP;O'Donnell,JP
通讯作者：
O'Donnell,JP