Regiocontrolled Gold-Catalyzed [2+2+2] Cycloadditions of Ynamides with Two Discrete Nitriles to Construct 4-Aminopyrimidine Cores
Regiocontrolled Gold-Catalyzed [2+2+2] Cycloadditions of Ynamides with Two Discrete Nitriles to Construct 4-Aminopyrimidine Cores
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DOI：
10.1002/anie.201405312
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发表时间：
2014-08-18
影响因子：
16.6
通讯作者：
Liu, Rai-Shung
中科院分区：
文献类型：
--
作者：
Karad, Somnath Narayan;Liu, Rai-Shung
本文报道了新型金催化的炔酰胺与两个离散腈的分子间[2+2+2]环加成反应，形成单体4-氨基嘧啶，这是药学上重要的结构基序。使用各种炔酰胺和腈获得的优异区域选择性证明了这种新环加成的实用性。
Reported herein is the novel gold-catalyzed intermolecular [2+2+2] cycloaddition of ynamides with two discrete nitriles to form monomeric 4-aminopyrimidines, which are pharmaceutically important structural motifs. The utility of this new cycloaddition is demonstrated by the excellent regioselectivity obtained using a variety of ynamides and nitriles.