The Classification of Lung Carcinoma: Time to Change the Morphology-Based Approach?
The Classification of Lung Carcinoma: Time to Change the Morphology-Based Approach?
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DOI：
10.1177/1066896910361736
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发表时间：
2010-06-01
影响因子：
1.2
通讯作者：
Viale, Giuseppe
中科院分区：
文献类型：
--
作者：
Pelosi, Giuseppe;Sonzogni, Angelica;Viale, Giuseppe
形态学仍然是肺癌分类的基石，并且始终伴随着病理学家的日常活动，尽管随着时间的推移，一些辅助技术已经被纳入以提高肺癌的诊断、预后和预测能力。目前，我们还面临着全球对肺癌治疗的重新思考，特别是在根据肿瘤的不同特征提出新的治疗策略后。尽管形态学仍然是肺癌分类中不易替代的工具，但我们现在面临的挑战是需要为临床医生提供更详细的非小细胞肺癌亚型，特别是在诊断材料有限、肿瘤分化差或不可切除病变的情况下。改进的形态学、免疫组织化学和分子测试的紧密结合不仅能够提高我们的诊断算法以及预后和预测潜力，而且还能深入了解一些肺癌生物学问题，例如组织发生和新的分类方案。
Morphology still remains the cornerstone in lung cancer classification and always has been accompanying pathologists in their daily activity, even though several ancillary techniques have been incorporated over time to improve diagnostic, prognostic, and predictive capabilities in lung cancer. Currently, we are also faced with a global rethinking of lung cancer care, especially once novel therapy strategies have been made available on the basis of the diverse characteristics of tumors. Although morphology still remains a not easily replaceable tool for lung cancer classification, we are now challenged by the need of offering clinicians more detailed subtyping of non-small-cell lung cancer especially in event of limited diagnostic material, poorly differentiated tumors, or unresectable lesions. Close integration of improved morphology, immunohistochemistry, and molecular tests will be able to not only sharpen our diagnostic algorithms and prognostic and predictive potentialities but also get insights into several lung cancer biology issues, such as histogenesis and new classification schemes.