TMS evidence for a selective role of the precuneus in source memory retrieval
TMS evidence for a selective role of the precuneus in source memory retrieval
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DOI：
10.1016/j.bbr.2014.12.032
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Koch, Giacomo
中科院分区：
文献类型：
--
作者：
Bonni, Sonia;Veniero, Domenica;Koch, Giacomo
包括楔前叶（PC）在内的后内侧皮层被认为参与情景记忆提取。在这里，我们使用连续θ爆发刺激（cTBS）解开楔前叶在识别记忆过程中的健康受试者的样本中的作用。在编码阶段，受试者被呈现一系列彩色图片。之后，在检索阶段，所有先前呈现的项目和新图片的样本都以黑色呈现，并要求受试者指出每个项目是新的还是旧的，如果是旧的，则要指出相关的颜色。在回收阶段之前，将cTBS递送到PC、后顶叶皮质（PPC）和头顶。分析了数据的命中，误报，源错误和遗漏。cTBS在楔前叶，但不是在PPC或顶点，诱导源记忆错误的选择性减少，表明上下文检索的改善。所有其他准确度测量值均保持不变。这些发现表明，楔前叶在成功的上下文相关检索的直接影响。(C)2015爱思唯尔B.V.保留所有权利。
The posteromedial cortex including the precuneus (PC) is thought to be involved in episodic memory retrieval. Here we used continuous theta burst stimulation (cTBS) to disentangle the role of the precuneus in the recognition memory process in a sample of healthy subjects. During the encoding phase, subjects were presented with a series of colored pictures. Afterwards, during the retrieval phase, all previously presented items and a sample of new pictures were presented in black, and subjects were asked to indicate whether each item was new or old, and in the latter case to indicate the associated color. cTBS was delivered over PC, posterior parietal cortex (PPC) and vertex before the retrieval phase. The data were analyzed in terms of hits, false alarms, source errors and omissions. cTBS over the precuneus, but not over the PPC or the vertex, induced a selective decrease in source memory errors, indicating an improvement in context retrieval. All the other accuracy measurements were unchanged. These findings suggest a direct implication of the precuneus in successful context-dependent retrieval. (C) 2015 Elsevier B.V. All rights reserved.