The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis
The systemic lupus erythematosus-associated PDCD1 polymorphism PD1.3A in lupus nephritis
复制标题
DOI：
10.1002/art.11442
复制
发表时间：
2004-01-01
影响因子：
--
通讯作者：
Alarcón-Riquelme, ME
中科院分区：
文献类型：
--
作者：
Prokunina, L;Gunnarsson, I;Alarcón-Riquelme, ME
系统性红斑狼疮（SLE）是一种自身免疫性炎症性疾病，在欧洲血统女性中的患病率为0.05-0.07%（1）。在各种器官系统，如皮肤，关节，肾脏和大脑的慢性炎症，以及对各种细胞内成分的反应性自身抗体的产生，是疾病的标志。家庭研究，双胞胎研究，分离分析提供了证据，在SLE的病因学中有很强的遗传成分，虽然遗传方式似乎是复杂的。可能有几个基因参与，具有不同的影响，与环境因素共同作用，产生个体发生SLE的总风险。由于疾病的遗传异质性，哪些基因、多少基因以及每个基因的影响将取决于所研究的人群。
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with a prevalence of 0.05–0.07% in women of European descent (1). Chronic inflammation in various organ systems such as the skin, joints, kidney, and brain, as well as production of reactive autoantibodies against a variety of intracellular components, are hallmarks of the disease.Family studies, twin studies, and segregation analyses have provided evidence of a strong genetic component in the etiology of SLE, although the mode of inheritance seems to be complex. There are probably several genes involved, with varying effects, acting together with environmental factors to produce the total risk of SLE development in an individual. Due to genetic heterogeneity of the disease, which genes, how many genes, and the impact of each gene will depend on the population studied.