Synthesis of 1,4-enynes via nickel-catalyzed cross-coupling of allylic alcohols with alkynylzinc reagents
Synthesis of 1,4-enynes via nickel-catalyzed cross-coupling of allylic alcohols with alkynylzinc reagents
复制标题
镍催化烯丙醇与炔基锌试剂交叉偶联合成 1,4-烯炔
DOI：
10.1039/d1cc05221g
复制
发表时间：
2021-10-20
影响因子：
4.9
通讯作者：
Wang, Zhong-Xia
中科院分区：
文献类型：
--
作者：
He, Xue-Yi;Wang, Zhong-Xia
1,4-烯炔的合成是通过烯丙醇与炔基锌试剂的镍催化交叉偶联进行的。当使用芳基取代的烯丙醇时，该反应具有高区域和 E/Z 选择性。该方法还表现出广泛的底物范围和良好的官能团兼容性。
Synthesis of 1,4-enynes was performed via nickel-catalyzed cross-coupling of allylic alcohols with alkynylzinc reagents. The reaction features high regio- and E/Z-selectivity when aryl-substituted allylic alcohols were employed. The method also exhibits a wide scope of substrates and good compatibility of functional groups.