INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism
INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism
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DOI：
10.1038/oby.2007.132
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发表时间：
2008-04-01
期刊：
影响因子：
6.9
通讯作者：
Kronenberg, Florian
中科院分区：
文献类型：
--
作者：
Boes, Eva;Kollerits, Barbara;Kronenberg, Florian
目的：既往的流行病学研究表明胰岛素诱导基因2（INSIG 2）与BMI相关。此外，在动物和细胞培养中的实验研究提供了证据，该基因可能参与脂蛋白和游离脂肪酸（FFA）代谢。因此，本研究的目的是检查INSIG 2基因附近的rs7566605变异体与BMI之间的关联，并将其扩展到肥胖的其他定量指标，以及脂蛋白和FFA代谢的参数。我们在一组严重肥胖的白色患者中对rs7566605进行了基因分型（n = 1，026），平均BMI为46.0 kg/m2，对照组（n = 818），以及来自奥地利的Salzburg动脉粥样硬化预防计划高个体风险受试者（SAPHIR）研究，结果：我们观察到来自犹他州的肥胖受试者和基于人群的对照者之间INSIG 2的rs7566605基因型频率没有差异。此外，我们没有发现与身体成分测量相关的证据（BMI、腰围、腰臀比、体脂百分比、内脏和皮下腹部脂肪量）或脂蛋白代谢（总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇、甘油三酯和游离脂肪酸）。讨论：我们的研究结果不支持INSIG 2基因与体重调节或脂蛋白代谢相关参数的关联。
Objective: A previous epidemiological study showed an association of the insulin-induced gene 2 ( INSIG2) gene with BMI. Additionally, experimental investigations in animals and cell culture provided evidence that this gene might be involved in lipoprotein and free fatty acid ( FFA) metabolism. Therefore, the aim of this study was to examine the association between the rs7566605 variant near the INSIG2 gene and BMI and to extend it to other quantitative measures of obesity, as well as parameters of lipoprotein and FFA metabolism.Methods and Procedures: We genotyped rs7566605 in a group of severely obese white patients ( n = 1,026) with an average BMI of 46.0 kg/ m(2) and a control group ( n = 818) from Utah, as well as in the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk ( SAPHIR) study from Austria, which is based on a healthy working population ( n = 1,696).Results: We observed no difference in the genotype frequency of rs7566605 of INSIG2 between obese subjects and population-based controls from Utah. Furthermore, we did not find evidence of an association with measures of body composition ( BMI, waist, waist-to-hip ratio, percentage body fat, amount of visceral and subcutaneous abdominal adipose fat) or lipoprotein metabolism ( total cholesterol, low-density lipoprotein ( LDL) and high-density lipoprotein ( HDL) cholesterol, triglycerides, and FFAs) in the Utah study population or in the independent SAPHIR study.Discussion: Our results do not support an association of the INSIG2 gene with the regulation of body weight or parameters related to lipoprotein metabolism.