STUDIES OF HUMAN TUMORS BY MRS - A REVIEW
STUDIES OF HUMAN TUMORS BY MRS - A REVIEW
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DOI：
10.1002/nbm.1940050518
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发表时间：
1992-09-01
影响因子：
2.9
通讯作者：
NEGENDANK, W
中科院分区：
文献类型：
--
作者：
NEGENDANK, W
本文综述了有关人体癌症中活体磷 - 21、氢 - 1、碳 - 13、钠 - 23和氟 - 19磁共振波谱（MRS）的文献。癌症在磷 - 31和氢 - 1磁共振波谱中具有典型的代谢特征，包括高水平的磷脂代谢物以及比正常更偏碱性的细胞pH值。这些特征单独来看并非癌症所特有，但在适当的临床环境中具有诊断价值。一些代谢特征似乎是预后指标，并且与治疗反应的相关性正逐渐成为MRS在肿瘤学中一种重要且潜在具有成本效益的应用。氟 - 19磁共振波谱可检测5 - 氟尿嘧啶的药代动力学，并且通过显示其滞留情况可预测癌症对治疗的反应。当前的需求包括通过使用多体素MRS、磷 - 31短回波时间的质子去耦以及脂肪抑制的氢 - 1磁共振波谱、直接或通过氢 - 1观测的碳 - 13磁共振波谱以及多种光谱特征的统计分析等技术来提高诊断特异性。需要在明确界定的临床环境中对大量人群进行试验，以确定MRS是否能够提供对癌症治疗有用的独立预后指标。
The literature describing P-21, H-1, C-13, Na-23 and F-19 MRS in vivo in human cancers is reviewed. Cancers have typical metabolic characteristics in P-31 and H-1 MRS including high levels of phospholipid metabolites and a cellular pH more alkaline than normal. These alone are not specific for cancer but are diagnostic in appropriate clinical settings. Some metabolic characteristics appear to be prognostic indices and correlation with treatment response is emerging as an important potentially cost-effective use of MRS in oncology. F-19 MRS examines pharmacokinetics of 5-fluorouracil and by demonstrating its retention predicts response of a cancer to treatment. Current needs include improvement of diagnostic specificity by use of techniques like multivoxel MRS, proton decoupling of P-31 short echo time and fat-suppressed H-1 MRS, C-13 MRS direct or via H-1-observe, and statistical analysis of multiple spectral features. Trials in large populations in well defined clinical settings are needed to determine if MRS can provide independent prognostic indices useful in cancer management.