Dual-drug delivery system based on hydrogel/micelle composites.
Dual-drug delivery system based on hydrogel/micelle composites.
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DOI：
10.1016/j.biomaterials.2009.01.006
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发表时间：
2009-05
期刊：
影响因子：
14
通讯作者：
Lan Wei;Chunhua Cai;Jiaping Lin;Tao Chen
中科院分区：
文献类型：
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作者：
Lan Wei;Chunhua Cai;Jiaping Lin;Tao Chen
本论文提出了一种水凝胶/多肽胶束复合物的双药传递系统。DDDS由阿司匹林（Asp）分散的聚乙烯醇（PVA）或壳聚糖（CS）/PVA水凝胶和阿霉素（DOX）负载的聚（L-谷氨酸）-b-聚（环氧丙烷）-b-聚（L-谷氨酸）（GPG）胶束构成。观察到两种药物的独立释放行为。在所有DDDS中，Asp具有短期释放行为，而DOX具有长期和持续释放行为。由于GPG胶束的pH和温度敏感性，DOX从所有DDDS中的释放是环境控制的。由于CS水凝胶的pH敏感性，Asp在CS/PVA/胶束DDDS中表现出pH控制释放行为。释放曲线采用Peppas提出的幂律方程进行分析。结果表明，在所有的水凝胶/胶束DDDS中，Asp的释放均为异常转运。DOX在PVA/胶束体系中的释放为Fickian型，在CS/PVA/胶束体系中，DOX的释放随释放指数n的增大而转变为反常传递。
We present a dual-drug delivery system (DDDS) of hydrogel/polypeptide micelle composites in this work. The DDDS was constructed from aspirin (Asp) dispersed poly(vinyl alcohol) (PVA) or Chitosan (CS)/PVA hydrogel and doxorubicin (DOX) loaded poly(l-glutamic acid)-b-poly(propylene oxide)-b-poly(l-glutamic acid) (GPG) micelles. Independent release behaviors of the two drugs are observed. Asp has a short-term release while DOX has a long-term and sustained release behavior in all the DDDSs. The release of DOX from all the DDDSs is environmentally controlled due to the pH and temperature sensitivity of the GPG micelle. Asp shows the pH controlled release behavior in CS/PVA/micelle DDDS due to the pH sensitivity of CS hydrogel. The releasing profiles were analyzed using a power law equation proposed by Peppas. It reveals that the release of Asp is anomalous transport in all the hydrogel/micelle DDDSs. The release of DOX is Fickian type in PVA/micelle system, and changes to anomalous transport in CS/PVA/micelle system according to the release exponent n.