Endometrial glandular and stromal breakdown, part 1: Cytomorphological appearance
Endometrial glandular and stromal breakdown, part 1: Cytomorphological appearance
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DOI：
10.1002/dc.20524
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发表时间：
2006-09-01
影响因子：
1.3
通讯作者：
Sakurai, Masami
中科院分区：
文献类型：
--
作者：
Shimizu, Keiko;Norimatsu, Yoshiaki;Sakurai, Masami
子宫内膜癌是女性生殖道最常见的侵袭性肿瘤。子宫内膜细胞学检查对这些病变及其前体的早期检测和准确诊断现已在日本被接受，并被认为是评价子宫内膜病理（不典型增生或癌）的有效的主要方法。对异常子宫内膜病变进行仔细的细胞形态学评价，可以进行准确和可重复的显微镜评估。本研究旨在探讨子宫内膜细胞学检查对无排卵相关的子宫内膜紊乱与子宫内膜增生的意义。1998年1月至2004年4月，对144例经Endocyte直接采集子宫内膜标本后行刮宫术获得组织病理学诊断的病例进行回顾性分析。材料包括49例正常增生期子宫内膜，63例无子宫内膜异位症的子宫内膜增生症作为对照。检查细胞形态学，包括所谓的子宫内膜腺和间质破裂（EGBD）。EGBD病例显示大量间质细胞凝聚并形成致密巢，细胞核深染，细胞质很少或没有。它们通常与子宫内膜腺体碎片簇和间质细胞密集簇相关。在细胞构筑学诊断上，子宫内膜腺体的碎裂簇和间质细胞的密集簇是EGBD子宫内膜的特征性细胞学特征。这些细胞模式的组合对EGBD子宫内膜的这种异常病理状态具有高度特异性。为提高细胞学诊断的准确性，对EGBD患者的子宫内膜细胞学检查应做到阴性，才能保证子宫内膜细胞学检查的成功
Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma). Careful cytomorphologic evaluation of the abnormal endometrial lesions has made possible an accurate and reproducible microscopic assessment. The current study was conducted to determine the significance of endometrial cytology on disordered endometrium associated with anovulation when compared with endometrial hyperplasia. From January 1998 through April 2004, 144 cases on which histopathological diagnoses were obtained by endometrial curettage after taken direct endometrial sample by Endocyte. The materials comprise 49 cases of normal proliferative endometrium, and 63 cases of endometrial hyperplasia without atypia were prepared as control cases. The cytomorphology was examined involving so-called endometrial glandular and stromal breakdown (EGBD). EGBD cases evidenced significant numbers of stromal cells condensed and formed compact nests with hyperchromatic nuclei and little or no cytoplasm. They were often associated with fragmented clusters of endometrial glands with condensed cluster of stromal cells. Both the fragmented cluster of endometrial glands and condensed cluster of stromal cells are a characteristic cytologic feature of EGBD endometrium on the cyto-architectural diagnosis. The combination of these cellular patterns is highly specific to this abnormal pathological condition in EGBD endometrium. To improve the accuracy of the cytodiagnosis, it is important that the cytology of the EGBD endometrium should be diagnosed negative; as a result, we can achieve successful endometrial cytology