Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates
Antibiotic prophylaxis before dental procedures may reduce the incidence of osteonecrosis of the jaw in patients with multiple myeloma treated with bisphosphonates
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DOI：
10.1080/10428190802483778
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Corradini, Paolo
中科院分区：
文献类型：
--
作者：
Montefusco, Vittorio;Gay, Francesca;Corradini, Paolo
颌骨坏死(ONJ)是接受双膦酸类药物治疗的多发性骨髓瘤(MM)患者的严重并发症。牙科手术是ONJ发生的主要危险因素。我们回顾分析了178例多发性骨髓瘤患者的资料，以评估在牙科手术前预防性使用抗生素是否可以预防ONJ。将牙科手术、抗生素预防、ONJ发生率与相关临床特征进行相关性分析。总体而言，178名患者中有9名发展为ONJ(5年粗略累积发病率：7.7%)。只有一例ONJ与牙科手术无关。75名患者接受了至少一次牙科手术，43名患者接受了抗生素预防。观察了8例ONJ患者，均为未使用抗生素预防的患者。唯一与ONJ显著相关的变量是抗生素预防(p=0.012)，它具有保护作用。因此，我们推测，抗生素预防可能会预防牙科手术后ONJ的发生。
Osteonecrosis of the jaw (ONJ) can be a severe complication of patients with multiple myeloma (MM) treated with bisphosphonates. Dental procedures are a major risk factor for ONJ occurrence. We retrospectively analysed the data of 178 patients with MM to evaluate if antibiotic prophylaxis before dental procedures may prevent ONJ. A correlation between dental procedures, antibiotic prophylaxis, incidence of ONJ and relevant clinical features was performed. Overall nine out of 178 patients developed ONJ (5 year crude cumulative incidence: 7.7%). Only one case of ONJ was not correlated with dental procedures. Seventy-five patients received at least one dental procedure and 43 received antibiotic prophylaxis. Eight cases of ONJ were observed, all in the group of patients without antibiotic prophylaxis. The only variable significantly associated with ONJ was antibiotic prophylaxis (p = 0.012), which had a protective effect. Thus, we speculated that antibiotic prophylaxis may prevent ONJ occurrence after dental procedures.