Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy.
Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy.
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DOI：
10.1021/acsnano.6b01401
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发表时间：
2016-04-26
期刊：
影响因子：
17.1
通讯作者：
Cai W
中科院分区：
文献类型：
--
作者：
Kamkaew A;Chen F;Zhan Y;Majewski RL;Cai W
由于难以将光传递到次表面，实现对深部肿瘤的有效治疗是传统光动力疗法（PDT）的主要挑战。由于其强大的组织穿透力，X射线有可能成为激活积聚在深部肿瘤组织中的光敏剂（PS）的理想激发源。最近，已经为此目的开发了各种各样的纳米颗粒。纳米粒子不仅可以作为载体负载各种PS，而且可以通过将X射线照射所获得的能量转移到负载的PS上来促进活化过程。本文综述了近年来纳米闪烁体的研究进展、合理设计以及在下一代光动力治疗中的应用。也将讨论使用放射性同位素作为内部光源治疗深部肿瘤。
Achieving effective treatment of deep-seated tumors is a major challenge for traditional photodynamic therapy (PDT) due to difficulties in delivering light into the sub-surface. Thanks to its great tissue penetration, X-rays hold the potential to become an ideal excitation source for activating photosensitizers (PS) that accumulate in deep tumor tissue. Recently, a wide variety of nanoparticles have been developed for this purpose. The nanoparticles are not only designed as carriers for loading various kinds of PSs, but also can facilitate the activation process by transferring energy harvested from X-ray irradiation to the loaded PS. In this review, we focus on recent developments of nanoscintillators with high energy transfer efficiency, their rational designs, as well as potential applications in next generation PDT. Treatment of deep-seated tumors by using radioisotopes as an internal light source will also be discussed.