Statin-induced improvements in vulnerable plaques are attenuated in poorly controlled diabetic patients with coronary atherosclerosis disease: a serial optical coherence tomography analysis
Statin-induced improvements in vulnerable plaques are attenuated in poorly controlled diabetic patients with coronary atherosclerosis disease: a serial optical coherence tomography analysis
复制标题
他汀类药物引起的易损斑块的改善在控制不佳的患有冠状动脉粥样硬化疾病的糖尿病患者中减弱：连续光学相干断层扫描分析。
DOI：
10.1007/s00592-016-0902-9
复制
发表时间：
2016-12-01
影响因子：
3.8
通讯作者：
Yu, Bo
中科院分区：
文献类型：
--
作者：
Dong, Nana;Xie, Zulong;Yu, Bo
目的糖尿病患者即使在接受降脂治疗后，心脏事件的发生率也会增加。本研究的目的是比较他汀类药物诱导的变化的特点，易损斑块的患者无糖尿病（DM）和那些控制较好或较差的DM，测量光学相干断层扫描（OCT）。方法这是一项回顾性研究99非罪犯富含脂质斑块从75例患者进行了密集的OCT成像检查。34名非糖尿病患者被分配到A组。根据平均HbA 1c水平将22例糖尿病患者分为B组，19例糖尿病患者分为C组（平均HbA 1c = 8%）。然而，斑块的纤维帽厚度增加在A组中最高（A组，183%; B组，104%;和C组，53%）。在A组和B组中观察到脂质体积指数显著降低（A组：-12%，P < 0.001; B组：-13%，P = 0.038; C组：7%，P = 0.948）。OCT测量的百分比变化显着相关平均HbA 1c在patients.Conclusions改善血糖控制可能会提高他汀类药物诱导减少的特点，在糖尿病患者的易损斑块。
Aims The incidence of cardiac events is increased in diabetic patients even after lipid-lowering therapy. This study aimed to compare the statin-induced changes in the characteristics of vulnerable plaques in patients without diabetes mellitus (DM) and in those with better-or poorly controlled DM, measured by optical coherence tomography (OCT).Methods This was a retrospective study of 99 non-culprit lipid-rich plaques from 75 patients who underwent intensive OCT imaging examination. Thirty-four non-diabetic patients were assigned to Group A. According to the average HbA1c level, 22 diabetic patients were assigned to Group B, and 19, to Group C (average HbA1c = 8 %, respectively).Results Following 12 months of statin therapy, similar improvements in serum lipid levels were observed in the three groups. However, the increase in fibrous-cap thickness of plaques was the highest in Group A (Group A, 183 %; Group B, 104 %; and Group C, 53 %). Significant reductions in lipid volume index were observed in Groups A and B (Group A: -12 %, P < 0.001; Group B: -13 %, P = 0.038; Group C: 7 %, P = 0.948). Percent changes in OCT measurements were significantly correlated with average HbA1c in patients.Conclusions Improved glucose control may enhance the statin-induced reduction in characteristics of vulnerable plaque in diabetic patients.