Liver Enzymes Concentrations Are Closely Related to Pre-diabetes: Findings of the Shanghai Diabetes Study II (SHDS II)
Liver Enzymes Concentrations Are Closely Related to Pre-diabetes: Findings of the Shanghai Diabetes Study II (SHDS II)
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DOI：
10.3967/0895-3988.2012.01.005
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发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
Jia Wei Ping
中科院分区：
文献类型：
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作者：
Gao Fei;Pan Jie Min;Jia Wei Ping
目的探讨上海市大规模人群肝酶与高血糖的关系，探讨肝酶与胰岛素抵抗的关系。每位参与者都接受了口服葡萄糖耐量试验并完成了问卷调查。结果肝酶浓度与i-IGT、IFG+IGT和糖尿病独立相关。随着ALT和GGT浓度的升高，i-IGT、IFG+IGT和DM的OR值逐渐升高。通过比较GGT浓度或ALT浓度最高四分位数的患者与最低四分位数（Q1）的患者，调整后i-IGT、IFG+IGT或糖尿病的OR具有显著性。ALT和GGT浓度与HOMA-IR呈线性相关，并与HOMA-IR独立相关[ALT OR（95%CI）：2.56（1.51-4.34）P=0.00; GGT OR（95% CI）：2.66（1.53-4.65）P=0.00]。结论血清ALT、GGT水平与术前病情密切相关。糖尿病和糖尿病与胰岛素抵抗呈正相关。
Objective To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.Methods A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.Results Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00].Conclusion Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.