Resection of liver metastases of colorectal carcinoma
Resection of liver metastases of colorectal carcinoma
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DOI：
10.1007/s002689900300
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发表时间：
1997-09-01
影响因子：
2.6
通讯作者：
Baba, S
中科院分区：
文献类型：
--
作者：
Nakamura, S;Suzuki, S;Baba, S
结直肠癌肝转移是危及生命的预后因素。目前的综述显示，肝切除术是最好的治疗方式，尽管肝切除术后转移性结直肠癌的总生存率仍然很低（20-40%）。许多作者分析的各种预后因素存在争议。肝转移瘤的数目和手术切缘是最重要的预后因素，如10篇文献所述，包括我们的数据。明确的手术切缘是可以实现的，但在肝脏有四个或更多转移性结节的患者的预后仍然很差。重复肝切除术也进行了评估，许多外科医生认为其死亡率可接受。在一定程度上提高了生存率。分析原发性和转移性肿瘤的生物学特性是非常重要和迫切需要的。
Hepatic metastasis of colorectal cancer is a life-threatening prognostic factor. The present review revealed that hepatic resection is the best treatment modality, although the overall survival rate after hepatectomy for metastatic colorectal cancer is still low (20-40%). Various prognostic factors analyzed by many authors are controversial. The number of hepatic metastases and the surgical margin were the most important prognostic factors, as seen in 10 papers previously reported including our data. A clear surgical margin is achievable, but the prognosis of patients with four or more metastatic nodules in the liver remains poor. Repeat hepatectomy is also evaluated and is believed by many surgeons to have acceptable mortality. It improved survival to a certain extent. Analysis of the biologic characteristics of primary and metastatic tumors is extremely important and is urgently indicated.