Intestinal fucose as a mediator of host-microbe symbiosis.
Intestinal fucose as a mediator of host-microbe symbiosis.
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DOI：
10.4049/jimmunol.1500395
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发表时间：
2015-06-15
期刊：
影响因子：
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通讯作者：
Chervonsky AV
中科院分区：
文献类型：
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作者：
Pickard JM;Chervonsky AV
Fucose is an L-configuration sugar found abundantly in the mammalian gut. It has long been known to be induced there by the presence of bacteria, but only recently have some of the molecular mechanisms behind this process been uncovered. New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. This review highlights recent studies showing that in addition to acting as a food source for beneficial gut symbionts, host fucose can also suppress the virulence of pathogens and pathobionts. The relevance of gut fucosylation to human diseases will also be discussed.
