Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine
Effects of adrenaline on circulatory dynamics and cardiac function in rats administered chlorpromazine
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肾上腺素对氯丙嗪大鼠循环动力学和心功能的影响
DOI：
10.1007/s10266-016-0241-x
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发表时间：
2016
期刊：
影响因子：
2.5
通讯作者：
Arisa Sakai Katsuhisa Sunada
中科院分区：
文献类型：
--
作者：
片岡華恵;牛山明;飯島 毅彦;片岡華恵，牛山明，飯島毅彦;Arisa Sakai Katsuhisa Sunada
我们的目的是阐明氯丙嗪（CPZ）和肾上腺素（AD）同时使用时循环动力学和心功能的变化。在大鼠体内置入动脉导管和左心室压力-容积测量导管。左大内收肌给药CPZ 10 mg/kg， 20 min后经舌给药生理盐水（NS）或AD 50 μg/kg。测量舒张末期容积（Ved）、收缩压（Pes）、卒中容积（SV）、卒中功（SW）、收缩末期容积弹性（Ees）、收缩压（SBP）、舒张压（DBP）和脉搏率（PR）。与对照组相比，AD给药后2 ~ 4 min和10 min时vedd显著降低；1 min显著降低；2 ~ 10 min显著增加；SV变化不显著，SW在1、2 min显著降低；1 ~ 3 min时收缩压和舒张压均低于对照组；PR在10min时升高。这些发现表明，当服用CPZ的患者在牙科治疗期间使用含有ad的局部麻醉剂时，存在血压暂时下降的风险。然而，几分钟后，血压恢复后负荷和心肌收缩力的增加。
We aimed to elucidate changes in circulatory dynamics and cardiac function during concomitant use of chlorpromazine (CPZ) and adrenaline (AD). An arterial line and left intraventricular pressure–volume measurement catheter were inserted in rats. CPZ 10 mg/kg was administered to the left great adductor muscle, followed by normal saline (NS) or AD 50 μg/kg through the tongue 20 min later. End-diastolic volume (Ved), end-systolic pressure (Pes), stroke volume (SV), stroke work (SW), end-systolic volume elastance (Ees), systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate (PR) were measured. Following AD administration,Vedsignificantly decreased at 2–4 and 10 min than that in control rats;Pessignificantly decreased at 1 min;Eessignificantly increased from 2 to 10 min; SV did not change significantly, and SW significantly reduced at 1 and 2 min; SBP and DBP were lower at 1–3 min than in the control; and PR increased at 10 min. These findings suggest that when AD-containing local anesthetics are administered during dental treatment of patients taking CPZ, there is a risk of a temporary drop in blood pressure. However, the blood pressure is recovered a few minutes later by the increase in afterload and the myocardial contractile force.