Circadian rhythm of bone formation biomarkers in serum of dromedary camels
Circadian rhythm of bone formation biomarkers in serum of dromedary camels
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DOI：
10.1016/j.rvsc.2010.03.024
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Al-Sobayil, F. A.
中科院分区：
文献类型：
--
作者：
Al-Sobayil, F. A.
研究了单峰骆驼血清中骨钙素和骨碱性磷酸酶（BAP）等骨形成生物标志物的昼夜节律。10只健康成年母骆驼每隔60 min采集血样，持续24 h。ELISA法测定血清骨钙素和BAP浓度。结果表明，骨钙素浓度在24 h内波动明显，最低和最高水平分别出现在13:00 （01:00 pm）和18:00 （06:00 pm）。BAP浓度有轻微波动，分别在凌晨1点和中午12点出现最低和最高水平。两种生物标志物之间的相关性较弱。结论：固定采血时间对分析骨钙素浓度有重要意义，而对BAP则无重要意义。(C) 2010 Elsevier Ltd.版权所有。
The circadian rhythm of biomarkers of bone formation including osteocalcin and bone alkaline phosphatase (BAP) was studied in the serum of dromedary camels. Blood samples were collected every 60 min for 24 h from 10 healthy adult female camels. ELISA was used to determine the concentrations of serum osteocalcin and BAP. The results showed a marked fluctuation in the concentration of osteocalcin during the 24 h period with minimum and maximum levels at 13:00 (01:00 pm) and 18:00 (06:00 pm), respectively. Slight fluctuation was observed in the concentration of BAP with minimum and maximum levels at 01:00 am and 12:00 pm, respectively. The correlation between the two biomarkers was weak. It was concluded that it is important to fix the time of blood sampling for analysis of osteocalcin concentrations, but not for BAP. (C) 2010 Elsevier Ltd. All rights reserved.