Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
复制标题
DOI：
10.7554/elife.58728
复制
发表时间：
2020-05-11
期刊：
影响因子：
7.7
通讯作者：
Weekes, Michael P.
中科院分区：
文献类型：
--
作者：
Rivett, Lucy;Sridhar, Sushmita;Weekes, Michael P.
各国之间在卫生保健工作者（HCW）SARS-CoV-2检测的可获得性方面存在显著差异，现有方案侧重于筛查有症状而非无症状的工作人员。在3周内（2020年4月），在英国一家大型教学医院对1032名无症状HCW进行了SARS-CoV-2筛查。对有症状的工作人员和有症状的家庭接触者进行了额外检测。实时RT PCR用于检测来自咽喉+鼻自拭子的病毒RNA。在无症状筛查组中，3%的医护人员检测出SARS-CoV-2阳性。17/30例（57%）为真正无症状/少症状。12/30（40%）在检测前7天以上出现了符合2019冠状病毒病（COVID-19）的症状，大多数自我隔离，恢复良好。在两个独立的病房中发现了HCW感染的聚集性。病毒基因组测序结果显示，大多数HCW具有优势谱系B。1.我们的数据证明了对症状轻微或无症状的HCW进行全面筛查的实用性。这种方法对于保护患者和医院工作人员至关重要。
Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT PCR was used to detect viral RNA from a throat +nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B. 1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff.