Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study.
Myelination of the brain in Major Depressive Disorder: An in vivo quantitative magnetic resonance imaging study.
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DOI：
10.1038/s41598-017-02062-y
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发表时间：
2017-05-19
影响因子：
4.6
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Sacchet MD;Gotlib IH
来自尸检、遗传、神经影像学和非人类动物研究的证据表明，重度抑郁症（MDD）与脑髓磷脂含量异常有关。本研究涉及的大脑区域，以及更普遍的MDD，包括伏隔核（NAcc）、外侧前额皮质（LPFC）、岛叶、亚属前扣带皮层（sgACC）和内侧前额皮质（mPFC）。我们研究了MDD是否以全脑水平以及NAcc、LPFC、岛、sgACC和mPFC的髓磷脂减少为特征。定量磁共振成像（qMRI）允许评估髓磷脂含量，在体内，在人脑通过R1的测量。在这项研究中，我们使用qMRI测量了40名MDD和40名健康对照（CTL）参与者的R1。我们发现，在全脑水平和NAcc中，MDD参与者的髓磷脂水平低于CTL参与者，并且在经历过多次抑郁发作的MDD参与者中，LPFC中的髓磷脂水平降低。尽管还需要进一步的研究来阐明髓磷脂在影响重度抑郁症的情绪、认知、行为和临床方面的作用，但目前的研究提供了重要的新证据，表明大脑成分的基本性质髓磷脂在这种疾病中发生了改变。
Evidence from post-mortem, genetic, neuroimaging, and non-human animal research suggests that Major Depressive Disorder (MDD) is associated with abnormalities in brain myelin content. Brain regions implicated in this research, and in MDD more generally, include the nucleus accumbens (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and medial prefrontal cortex (mPFC). We examined whether MDD is characterized by reduced myelin at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC. Quantitative magnetic resonance imaging (qMRI) permits the assessment of myelin content, in vivo, in the human brain through the measure of R1. In this study we used qMRI to measure R1 in 40 MDD and 40 healthy control (CTL) participants. We found that the MDD participants had lower levels of myelin than did the CTL participants at the whole-brain level and in the NAcc, and that myelin in the LPFC was reduced in MDD participants who had experienced a greater number of depressive episodes. Although further research is needed to elucidate the role of myelin in affecting emotional, cognitive, behavioral, and clinical aspects of MDD, the current study provides important new evidence that a fundamental property of brain composition, myelin, is altered in this disorder.