Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion.
Phospholipase A2 sensitivity of the dorsal root and dorsal root ganglion.
复制标题
背根和背根神经节的磷脂酶A2敏感性。
DOI：
10.1097/00007632-199806150-00002
复制
发表时间：
1998
期刊：
影响因子：
3
通讯作者：
Cavanaugh,JM
中科院分区：
文献类型：
--
作者：
Ozaktay,AC;Kallakuri,S;Cavanaugh,JM
Study Design.This study was designed to characterize the effects of phospholipase A 2 on the neural response of dorsal root and dorsal root ganglion in the anesthetized New Zealand White rabbit.Objectives.To examine the effects of phospholipase A 2 on the neural response of somatosensory neurons at the dorsal root ganglion level.Summary of Background Data.Phospholipase A 2 may be an irritating component of disc tissue that is present in high concentration in painful herniated discs, in synovial fluids, and in sera of rheumatoid arthritis patients. Phospholipase A 2 is inflammatory; however, its effects on dorsal roots and dorsal root ganglion response have never been demonstrated.Methods.Surgically isolated dorsal roots and dorsal root ganglia from New Zealand White rabbits were investigated by electrophysiologic techniques. Phospholipase A 2 doses ranging from 100 to 400 U were applied on the mechanically sensitive segments of the dorsal root ganglia, and responses to varying doses were evaluated in relation to elapsed time.Results.The application of phospholipase A 2 on the dorsal root ganglion resulted in possible neurotoxicity at doses more than 375 U, with no significant effect at lower doses except for recruitment of" silent units" at doses ranging from 200 to 340 U.Conclusions.Phospholipase A 2 doses comparable to serum concentrations in human rheumatoid arthritis appeared to be neurotoxic when applied to dorsal root ganglia. At lower doses, silent units become activated that were not active before the phospholipase A 2 application. These results suggest that dorsal roots and dorsal root ganglion may be impaired by phospholipase A 2, leading to sciatica and low back pain.
