Human hippocampus associates information in memory
Human hippocampus associates information in memory
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DOI：
10.1073/pnas.96.10.5884
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发表时间：
1999-05-11
影响因子：
11.1
通讯作者：
Buck, A
中科院分区：
文献类型：
--
作者：
Henke, K;Weber, B;Buck, A
海马结构是人类大脑中最复杂、最脆弱的结构之一，是维持长期记忆的重要脑区。然而，它在记忆中的具体功能是有争议的。最近的实验结果表明，海马对人类记忆的贡献仅限于情景记忆，新奇检测，信息的语义（深）处理和空间记忆。我们用正电子发射断层扫描仪测量了健康志愿者在用不同学习策略学习成对单词时的局部脑血流量。这些导致了不同形式的学习，使我们能够测试它们挑战海马功能的程度。无论是新奇的发现，还是深度的处理，都没有激活海马结构，就像在记忆中语义上联系基本上不相关的单词一样。这是令人信服的证据，证明人类海马结构在记忆中的另一个功能：建立语义联系。
The hippocampal formation, one of the most complex and vulnerable brain structures, is recognized as a crucial brain area subserving human long-term memory. Yet, its specific functions in memory are controversial. Recent experimental results suggest that the hippocampal contribution to human memory is limited to episodic memory, novelty detection, semantic (deep) processing of information, and spatial memory. We measured the regional cerebral blood flow by positron-emission tomography while healthy volunteers learned pairs of words with different learning strategies. These led to different forms of learning, allowing us to test the degree to which they challenge hippocampal function. Neither novelty detection nor depth of processing activated the hippocampal formation as much as semantically associating the primarily unrelated words in memory. This is compelling evidence for another function of the human hippocampal formation in memory: establishing semantic associations.