Pharmacokinetics of isoflurane: Uptake in the body
Pharmacokinetics of isoflurane: Uptake in the body
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DOI：
10.1159/000072665
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发表时间：
2003-11-01
期刊：
影响因子：
3.1
通讯作者：
Lin, CY
中科院分区：
文献类型：
--
作者：
Lu, CC;Ho, ST;Lin, CY
本研究通过比较16例冠状动脉搭桥手术患者在异氟醚麻醉1小时内肺动脉血（PAiso）和动脉血（Aiso）中异氟醚的浓度，探讨吸入异氟醚浓度（C(I)iso）对机体摄取的影响。患者接受芬太尼和硫喷妥钠组成的标准化麻醉剂，然后被分配接受1%或2% C(I)iso（每组n = 8）。红外分析测定C(1)iso和潮末异氟烷浓度（C(E)iso），气相色谱分析Aiso和PAiso。采用肺动脉导管热稀释法测定心输出量。随着时间的推移，身体组织可以分别用梯度C(I)iso-C(E)iso或Aiso-PAiso来表示。2%异氟醚吸入组的梯度(C（I)iso-C(E)iso或Aiso-PAiso）是1%异氟醚吸入组的两倍。此外，C(I)iso-C(E)iso和Aiso-PAiso在研究过程中几乎保持不变。随着时间的推移，异氟烷的激发浓度依赖性和接近恒定的摄取具有重要的意义，使我们能够将异氟烷的摄取模式应用于临床实践。版权所有(C) 2003 S. Karger AG，巴塞尔。
We investigated the effect of the inspired isoflurane concentration (C(I)iso) on body uptake by comparing the isoflurane concentration in the pulmonary artery blood (PAiso) and that in the arterial blood (Aiso) in 16 patients undergoing coronary artery bypass grafting surgery during the 1st, hour of isoflurane anesthesia. The patients received standardized anesthetics consisting of fentanyl and thiopental and were then allocated to receive either 1% or 2% C(I)iso (n = 8 in each group). C(1)iso and end-tidal isoflurane concentration (C(E)iso) were measured by infrared analysis, and Aiso and PAiso were analyzed by gas chromatography. The cardiac output was measured by thermodilution by use of a pulmonary artery catheter. The body tissue could be represented by the gradient C(I)iso-C(E)iso or Aiso-PAiso over time, respectively. The 2% inspired isoflurane group had twice the gradients (either C(I)iso-C(E)iso or Aiso-PAiso) than the 1% inspired isoflurance group. Additionally, both C(I)iso-C(E)iso and Aiso-PAiso were nearly constant over the hour of the study. The inspired concentration-dependent and near-constant uptake of isoflurane over time has important implications which enable us to apply the uptake pattern of isoflurane to clinical practice. Copyright (C) 2003 S. Karger AG, Basel.