Acute stress persistently enhances estrogen levels in the female rat.
Acute stress persistently enhances estrogen levels in the female rat.
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DOI：
10.3109/10253899909001120
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发表时间：
1999-12-01
期刊：
影响因子：
--
通讯作者：
Paczynski, M
中科院分区：
文献类型：
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作者：
Shors, T J;Pickett, J;Paczynski, M
在这里，我们测试了暴露于尾震或游泳应激是否会改变雌性的卵巢激素水平，雌激素和孕激素，以及这种影响是否是持久的。还测量了雄性和雌性动物的肾上腺激素水平。在发情前期，雌激素水平升高，相对于女性在其他阶段的发情期，暴露于压力增强雌二醇超过基础水平。对于雌性强调在动情间期2，雌二醇水平升高后立即停止应激和长达24小时。暴露于尾震，但不是游泳应激，短暂增强孕酮的雌性强调在发情前期和发情期的阶段。糖皮质激素水平在两种压力源的反应中均升高，并且在基础和压力条件下，雌性动物的糖皮质激素水平相对于雄性动物均超高，特别是在暴露于急性游泳压力的雌性动物的血液中。这些结果表明，暴露于一个相对急性的应激事件立即和持续提高血清雌二醇和讨论的背景下，暴露于相同的应激源立即和持续损害联想学习的雌性大鼠的报告。
Here we tested whether exposure to either tailshock or swim stress alters ovarian hormone levels, estrogen and progesterone, in females and whether the effects are persistent. Adrenal hormone levels were also measured in males and females. Estradiol levels were elevated in unstressed females during proestrus relative to females in other stages of estrous, and exposure to the stressors enhanced estradiol beyond basal levels. For females stressed during diestrus 2, estradiol levels were elevated immediately after stressor cessation and up to 24 hrs. Exposure to tailshock, but not swim-stress, transiently enhanced progesterone in females stressed during the stage of proestrus and estrus. Glucocorticoid levels were elevated in response to both stressors and were supraelevated in females under both basal and stress conditions relative to males, particularly in blood from females exposed to acute swim stress. These results indicate that exposure to a relatively acute stressful event immediately and persistently enhances serum estradiol and are discussed in the context of reports that exposure to the same stressors immediately and persistently impairs associative learning in the female rat.