The importance of plasma concentration in addition apolipoprotein E to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
The importance of plasma concentration in addition apolipoprotein E to its common polymorphism on inter-individual variation in lipid levels: results from Apo Europe
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DOI：
10.1038/sj.ejhg.5200864
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发表时间：
2002-12-01
影响因子：
5.2
通讯作者：
Visvikis, S
中科院分区：
文献类型：
--
作者：
Haddy, N;De Bacquer, D;Visvikis, S
与冠状动脉疾病（CAD）风险相关的血脂浓度的个体间差异是由遗传和环境因素共同决定的。本研究调查了来自芬兰、法国、北方爱尔兰、葡萄牙和西班牙的受试者中apoE基因型和血浆浓度对胆固醇和甘油三酯（TG）水平的影响。年龄和性别显著影响血清胆固醇、TG和apoE浓度。年龄效应在男性和女性中不同。apoE基因是研究最广泛的CAD易感基因之一，其等位基因频率的测定结果表明：ε 2等位基因频率和apoE浓度呈南北递增梯度，而ε 4等位基因频率则相反。ApoE在脂质代谢中起重要作用。总胆固醇和TG浓度显着依赖于载脂蛋白E基因型在两种性别。当考虑到血浆apoE浓度时，基因型之间脂质的这些差异更加明显。
Interindividual variation in the concentration of plasma lipids which are associated with coronary artery disease (CAD) risk is determined by a combination of genetic and environmental factors. This study investigates the effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain. Age and sex significantly influenced serum cholesterol, TG and apoE concentrations. The age effect differs in males and females. The allele frequencies of the apoE gene, one of the most widely studied CAD susceptibility genes, were determined: the epsilon2 allele frequency and the apoE concentration showed a north-south increasing gradient while the epsilon4 allele frequency showed the reverse. ApoE plays an important role in lipid metabolism. Total cholesterol and TG concentrations were significantly dependent on apoE genotype in both sexes. These differences in lipids between genotypes were more pronounced when plasma apoE concentrations were taken into account.