Multifaceted role of branched-chain amino acid metabolism in cancer.
Multifaceted role of branched-chain amino acid metabolism in cancer.
复制标题
支链氨基酸代谢在癌症中的多方面作用。
DOI：
10.1038/s41388-020-01480-z
复制
发表时间：
2020-10
期刊：
影响因子：
8
通讯作者：
Luo W
中科院分区：
文献类型：
--
作者：
Peng H;Wang Y;Luo W
代谢重编程满足了增加的营养需求，并调节了肿瘤中的许多致癌过程，导致了肿瘤的恶性。支链氨基酸(BCAA，即缬氨酸、亮氨酸和异亮氨酸)作为氮供体产生核苷酸等大分子，对人类癌细胞的生长是不可或缺的。支链氨基酸代谢改变的细胞自主和非自主作用与癌症的进展有关，支链氨基酸代谢途径中的关键蛋白可能是人类癌症的预后和诊断生物标志物。在这里，我们总结了支链氨基酸代谢重编程是如何在癌细胞中被调控的，以及它是如何影响癌症进展的。
Metabolic reprogramming fulfils increased nutrient demands and regulates numerous oncogenic processes in tumors, leading to tumor malignancy. Branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules such as nucleotides and are indispensable for human cancer cell growth. The cell-autonomous and non-autonomous roles of altered BCAA metabolism have been implicated in cancer progression and the key proteins in the BCAA metabolic pathway serve as possible prognostic and diagnostic biomarkers in human cancers. Here we summarize how BCAA metabolic reprogramming is regulated in cancer cells and how it influences cancer progression.