REDEFINITION OF NORMAL ACID-BASE-EQUILIBRIUM IN MAN - CARBON-DIOXIDE TENSION AS A KEY DETERMINANT OF NORMAL PLASMA BICARBONATE CONCENTRATION
REDEFINITION OF NORMAL ACID-BASE-EQUILIBRIUM IN MAN - CARBON-DIOXIDE TENSION AS A KEY DETERMINANT OF NORMAL PLASMA BICARBONATE CONCENTRATION
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DOI：
10.1038/ki.1979.171
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发表时间：
1979-01-01
影响因子：
19.6
通讯作者：
SCHWARTZ, WB
中科院分区：
文献类型：
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作者：
MADIAS, NE;ADROGUE, HJ;SCHWARTZ, WB
犬的正常酸碱平衡的特征是血浆碳酸氢盐浓度与P [分压] CO2之间存在强正相关性。在人类中，可能也存在PCO2正常水平和血浆碳酸氢盐之间的类似关系。正常范围内的碳酸氢盐值高度依赖于PCO2的普遍水平。碳酸氢盐浓度中约50%的正常方差可简单地由PCO2的方差解释。碳酸氢盐浓度和PCO2的联合置信区域，可以从这些数据中得出，提供了一个新的和更严格的定义正常的酸碱平衡的人。
Normal acid-base equilibrium in the dog is characterized by a strong positive correlation between plasma bicarbonate concentration and P[partial pressure]CO2. A similar relationship between normal levels of PCO2 and plasma bicarbonate might be present in man. Values for bicarbonate within the normal range are highly dependent upon the prevailing level of PCO2. Approximately 50% of the normal variance in bicarbonate concentration is explained simply by the variance in PCO2. The joint confidence region for bicarbonate concentration and PCO2 that can be derived from these data provides a new and more rigorous definition of normal acid-base equilibrium in man.