Quantum dot-pseudopolyrotaxane supramolecules as anticancer drug delivery systems
Quantum dot-pseudopolyrotaxane supramolecules as anticancer drug delivery systems
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DOI：
10.1016/j.polymer.2011.02.032
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发表时间：
2011-05-13
期刊：
影响因子：
4.6
通讯作者：
Attyabi, Fatemeh
中科院分区：
文献类型：
--
作者：
Adeli, Mohsen;Hakimpoor, Farahman;Attyabi, Fatemeh
合成并表征了由α-环糊精环、聚乙二醇轴和末端三嗪基团组成的拟聚轮烷（Ps-PR）。通过其末端三嗪基团与缀合到量子点（β-CD-接枝-QD）表面的β-环糊精之间的主客关系，避免了α-环糊精环从聚乙二醇轴上解离，从而产生了一种新型动态聚轮烷，其中QD以非共价键方式发挥终止剂的作用。合成的超分子的稳定性取决于 Ps-PR 和 β-CD-graft-QD 末端三嗪基团之间的宿主客体关系的效率，通过这种关系控制 α-环糊精环从聚乙二醇轴的释放。肿瘤识别模块与其塞子结合，并在癌细胞（小鼠结肠腺癌肿瘤 C26）内进行受体介导的内吞作用和释放。然后，事实证明这些肿瘤靶向 DDS 是未来癌症治疗的有前途的系统。还研究了与塞子官能团结合的药物的释放速率。 (C) 2011 Elsevier Ltd. 保留所有权利。
Pseudopolyrotaxanes (Ps-PR) consisting of alpha-cyclodextrin rings, polyethylene glycol axes and end triazine groups were synthesized and characterized. Dissociation of the alpha-cyclodextrin rings from the polyethylene glycol axes was avoided by the host guest relationship between its end triazine groups and beta-cyclodextrins conjugated onto the surface of quantum dots (beta-CD-graft-QDs), leading to a new type of the dynamic polyrotaxanes in which QDs play the role of stoppers noncovalently. Stability of the synthesized supramolecules was depended on the efficiency of the host guest relationships between the end triazine groups of Ps-PR and beta-CD-graft-QDs through which release of alpha-cyclodextrin rings from the polyethylene glycol axes was controlled.To prove the efficacy of the synthesized supramolecules as drug delivery systems (DDSs) cisplatin (Cis-Diamminedichloroplatinum (CDDP) a platinum-based chemotherapy drug) and folic acid as a tumor-recognition module were conjugated to their stoppers and they were subjected to the receptor-mediated endocytosis and release inside the cancer cells, murine colon adenocarcinoma tumor C26. Then, it was proved that these tumor-targeting DDSs are promising systems for future cancer therapy. Rate of the release of the drugs, conjugated to the functional groups of stoppers was also investigated. (C) 2011 Elsevier Ltd. All rights reserved.