Aggravation of experimental glomerulonephritis by superimposed clip hypertension.
Aggravation of experimental glomerulonephritis by superimposed clip hypertension.
复制标题
叠加夹压高血压加重实验性肾小球肾炎。
作者：
J. Neugarten;H. Feiner;R. Schacht;G. Gallo;D. Baldwin
为了评估高血压对肾小球肾炎的临床和形态学特征的可能增强作用，在雌性Sprague-Dawley大鼠中将双肾夹高血压（CH）叠加在轻度形式的肾毒性血清肾炎（NSN）上。在6个月内定期评估以下参数：血压（BP）、心脏重量、蛋白尿（UpV）和肾脏形态。血压和心脏重量增加同样在夹高血压和肾毒性血清肾炎合并夹高血压。单纯肾毒性血清肾炎（49 ± 28 mg/24 hr）或夹子性高血压（40 ± 22 mg/24 hr）仅发生中度蛋白尿，而肾毒性血清肾炎合并夹子性高血压5个月后出现重度蛋白尿（161 ± 36 mg/24 hr）（P <0.001）。肾毒性血清肾炎的肾小球组织学显示罕见的局灶性和节段性增生和最小硬化;血管正常。夹型高血压的特点是罕见的和轻度的血管硬化和肾小球增生和硬化。严重的肾小球内和毛细血管外的增殖和广泛的肾小球和血管硬化发生在大多数大鼠时，肾毒性血清肾炎与夹高血压相结合。这些数据表明，夹高血压增强肾小球增生和硬化，并导致在实验性肾炎血管硬化的发展。
To evaluate the possible enhancing effect of hypertension on the clinical and morphologic features of glomerulonephritis, two-kidney clip hypertension (CH) was superimposed on a mild form of nephrotoxic serum nephritis (NSN) in female Sprague-Dawley rats. The following parameters were assessed regularly over a 6-month period: blood pressure (BP), heart weight, proteinuria (UpV), and renal morphology. Blood pressure and heart weights were increased equally in clip hypertension and in nephrotoxic serum nephritis combined with clip hypertension. While only moderate proteinuria occurred in nephrotoxic serum nephritis (49 +/- 28 mg/24 hr) or clip hypertension (40 +/- 22 mg/24 hr) alone, the superimposition of clip hypertension on nephrotoxic serum nephritis resulted in heavy proteinuria (161 +/- 36 mg/24 hr) (P less than 0.001) after 5 months of hypertension. Glomerular histology in nephrotoxic serum nephritis showed infrequent focal and segmental proliferation and minimal sclerosis; vessels were normal. Clip hypertension was characterized by infrequent and mild vascular sclerosis and glomerular proliferation and sclerosis. Severe glomerular endo- and extracapillary proliferation and widespread glomerular and vascular sclerosis occurred in the majority of rats when nephrotoxic serum nephritis was combined with clip hypertension. The data demonstrate that clip hypertension enhances glomerular proliferation and sclerosis and results in the development of vascular sclerosis in experimental nephritis.