The subthalamic nucleus during decision-making with multiple alternatives.
The subthalamic nucleus during decision-making with multiple alternatives.
复制标题
DOI：
10.1002/hbm.22896
复制
发表时间：
2015-10
影响因子：
4.8
通讯作者：
Forstmann BU
中科院分区：
文献类型：
--
作者：
Keuken MC;Van Maanen L;Bogacz R;Schäfer A;Neumann J;Turner R;Forstmann BU
几个著名的神经计算模型预测，选择替代品的增加受到丘脑底核(STN)活动增加的调节。反过来，STN活动的增加又允许信息的长期积累。同时，假设额叶内侧皮质的前扣带回(ACC)和前扣带回(Pre-SMA)等区域会影响STN的信息加工。这项研究开始使用7特斯拉结构和功能磁共振成像的多模式组合以及祖先图(AG)建模来测试在多选择决策中对STN活动的具体预测。结果与预测一致，因为STN活跃度随着选择选项的增加而增加。此外，我们的研究表明，ACC的活性与STN的活性相关，而不是直接调节它。这一结果为了解内侧额叶皮质和基底节之间的信息处理流提供了新的线索。
Several prominent neurocomputational models predict that an increase of choice alternatives is modulated by increased activity in the subthalamic nucleus (STN). In turn, increased STN activity allows prolonged accumulation of information. At the same time, areas in the medial frontal cortex such as the anterior cingulate cortex (ACC) and the pre-SMA are hypothesized to influence the information processing in the STN. This study set out to test concrete predictions of STN activity in multiple-alternative decision-making using a multimodal combination of 7 Tesla structural and functional Magnetic Resonance Imaging, and ancestral graph (AG) modeling. The results are in line with the predictions in that increased STN activity was found with an increasing amount of choice alternatives. In addition, our study shows that activity in the ACC is correlated with activity in the STN without directly modulating it. This result sheds new light on the information processing streams between medial frontal cortex and the basal ganglia.